小儿抗生素相关性腹泻采用匹多莫德治疗的效果及对免疫功能和炎症因子的影响

Curative effect of pidotimod on inflammation factors and immune function of antibiotics associated diarrhea children

目的:探讨小儿抗生素相关性腹泻采用匹多莫德治疗的效果及对免疫功能和炎症因子的影响。方法:根据随机数字表法将82例抗生素相关性腹泻患儿分为观察组和对照组,每组41例,两组患儿均给予等常规对症治疗,在此基础上,观察组患儿给予匹多莫德治疗,两组均治疗2周,比较临床疗效和治疗前后免疫球蛋白:IgA、IgG、IgM,T细胞亚群:CD3+、CD4+、CD8+、CD4+/CD8+,炎症因子:肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)的水平变化。结果 :对照组总有效率为75.61%,观察组为95.12%,两组比较,差异显著(P<0.05);两组治疗后CD3+、CD4+、CD4+/CD8+、IgA、IgG均较治疗前显著升高,TNF-α、IL-6均较治疗前显著降低,差异有统计学意义(P<0.05);观察组上述指标变化的幅度大于对照组,差异有统计学意义(P<0.05)。结论:匹多莫德治疗小儿抗生素相关性腹泻疗效显著,能降低炎症反应,提高机体免疫力。

Objective：To explore the curative effect of pidotimod on inflammation factors and immune function of antibiotics associated diarrhea children.Methods：A total of 82 cases antibiotic associated diarrhea children were divided into control group and observation group according to random number table method,with 41 cases in each group.Children in two groups were given conventional treatment,on this basis,children in observation group were with pidotimod treatment for 2weeks.Clinical efficacy and immune globulin：IgA,IgG,IgM,T cell subgroup：CD3^＋,CD4^＋,CD8^＋,CD4^＋/CD8^＋,and inflammation factors：tumor necrosis factor-α（TNF-α）and interleukin 6（IL-6）were compared.Results：The total effective rate in control group was 75.61%,it was significantly lower than 95.12% in observation group;The levels of CD3^＋,CD4^＋,CD4^＋/CD8^＋,IgA,IgG after treatment in two groups were significantly rised while the levels of TNF-α,IL-6were significantly reduced than before treatment,The amplitude of index above in observation group was greater than the control group（P〈0.05）.Conclusions：The curative effect of pidotimodi on antibiotics associated diarrhea children is obvious.It can reduce inflammation,and improve immunity.