彩色多普勒超声测定子痫前期患者子宫动脉S/D、PI、RI及其与病情严重程度的相关性

Color Doppler ultrasound detection of uterine artery S/D,PI and RI in patients with preeclampsia and their correlation with disease severity

目的:研究彩色多普勒超声测定子痫前期患者子宫动脉的S/D、PI、RI及其与病情严重程度的相关性。方法:选择子痫前期孕妇作为PE组、健康孕妇作为NOR组,进行彩色多普勒超声检查并测定子宫动脉的S/D、PI、RI,采集血清并测定血管新生相关细胞因子的含量,采集胎盘组织并测定蛋白酶及抑制分子、氧化应激分子、抗凋亡分子的含量。结果:PE组孕妇的S/D、PI、RI均显著高于NOR组;PE组孕妇血清中PIGF、VEGF、PAPP-A的含量显著低于NOR组且与S/D、PI、RI呈负相关,sVEGFR-1、Kisspeptin-10的含量显著高于NOR组且与S/D、PI、RI呈正相关;PE组胎盘组织中CTSB、CTSL、MMP3、MMP9、SOD、GST、VitC、VitE、辅酶Q10以及Xiap、Survivin的含量低于NOR组且与S/D、PI、RI呈负相关,TIMP1、TIMP2、TIMP3、RECK的含量高于NOR组且与S/D、PI、RI正相关。结论:子痫前期患者子宫动脉的S/D、PI、RI显著增加,能够评估患者体内的血管新生情况、细胞侵袭情况、抗凋亡情况以及氧化应激情况。

Objective：To study color Doppler ultrasound detection of uterine artery S/D,PI and RI in patients with preeclampsia and their correlation with disease severity.Methods：Pregnant women with preeclampsia were selected as PE group,healthy pregnant women were the NOR group,color Doppler ultrasound detection was conducted to detect uterine artery S/D,PI and RI,serum was collected to detect the contents of angiogenesis-related cytokines,and placenta tissue was collected to detect the contents of proteases as well as inhibitors,oxidative stress molecules and anti-apoptotic molecules.Results：S/D,PI and RI of PE group were significantly higher than those of NOR group;serum PIGF,VEGF and PAPP-A contents of PE group were significantly lower than those of NOR group and negatively correlated with S/D,PI and RI while sVEGFR-1and Kisspeptin-10 contents were significantly higher than those of NOR group and positively correlated with S/D,PI and RI;CTSB,CTSL,MMP3,MMP9,SOD,GST,VitC,VitE and coenzyme Q10 as well as Xiap and Survivin contents in placenta tissue of PE group were lower than those of NOR group and negatively correlated with S/D,PI and RI while TIMP1,TIMP2,TIMP3 and RECK contents were higher than those of NOR group and positively correlated with S/D,PI and RI.Conclusion：Uterine artery S/D,PI and RI significantly increase in patients with preeclampsia,and can assess the angiogenesis,cell invasion,anti-apoptosis and oxidative stress in patients.