2型糖尿病血清血管生成素样蛋白2水平与颈动脉斑块性质的相关性研究

Correlation between serum Angptl2 level and carotid plaque in Type 2 diabetes

目的：分析2型糖尿病血清血管生成素样蛋白2水平与颈动脉斑块性质的相关性。方法：将2012年8月～2015年12月间在本院住院治疗的2型糖尿病患者118例作为观察组对象,均经B超及CT动脉血管造影检查伴有不同程度的颈动脉斑块,根据斑块程度不同分为不稳定性斑块组（n=56）及稳定性斑块组（n=62）,另取同期在本院接受血糖调节治疗的单纯2型糖尿病（不伴有颈动脉斑块）患者97例作为对照组。检测各组患者的血清血管生成素样蛋白2（Angptl2）水平及颈动脉斑块性质相关指标值,并进一步分析两者之间存在的相关关系。结果：观察组患者的血清Angptl2水平显著高于对照组,其中不稳定斑块患者血清Angptl2水平高于稳定性斑块组患者（P〈0.05）;观察组患者的血清Fbg、HbA1c、bigET-1值高于对照组患者,DBIL、RHI值低于对照组患者;观察组患者的血清cystatin c、visfatin值高于对照组患者,ApoA1、MPO值低于对照组患者（P〈0.05）;观察组患者的血清ACA、MIF、sCD40L、PAPP-A、CXCR16、t-HCY及D-二聚体值高于对照组患者（P〈0.05）;血清Angptl2水平与Fng、HbA1c、bigET-1、cystatin c、ApoA1、visfatin、ACA、MIF、sCD40L、PAPP-A、CXCR16、tHCY及D-二聚体水平呈正比,与DBIL、RHI、MPO值呈反比（P〈0.05）。结论：2型糖尿病患者伴颈动脉斑块患者存在显著Angptl2水平异常,且与斑块性质相关指标存在直接相关关系,是判断患者病情并预测疾病结局的可靠指标。

Objective：To analyze the correlation between serum Angptl2 level and carotid plaque nature in Type 2diabetes.Methods：A total of 118 cases of Type 2diabetes hospitalized in our hospital from August 2012 to December 2015 were selected as subjects of observation group.They were accompanied with different degree of carotid plaque shown in B ultrasound and CT coronary arterial angiography examination,and were divided into unstable plaque group（n=56）and stable plaque group（n=62）according to the degree of plaque,and 97 cases of patients with Type 2diabetes alone（not complicated with carotid plaque）who received blood glucose regulation treatment in our hospital during the same period were the control group.Serum Angptl2 levels and the values of carotid plaque nature-related indexes of all groups were detected,and the correlation between the two was further analyzed.Results：Serum Angptl2 level of observation group was significantly higher than that of control group,and serum Angptl2 level of unstable plaque group was higher than that of stable plaque group（P〈0.05）;serum Fbg,HbA1 cand bigET-1values of observation group were higher than those of control group while DBIL and RHI values were lower than those of control group;serum cystatin c and visfatin values of observation group were higher than those of control group while ApoA1 and MPO values were lower than those of control group（P〈0.05）;serum ACA,MIF,sCD40 L,PAPP-A,CXCR16,t-HCY and D-dimer values of observation group were higher than those of control group（P〈0.05）;serum Angptl2 level was directly proportional to Fng,HbA1 c,bigET-1,cystatin c,ApoA1,visfatin,ACA,MIF,sCD40 L,PAPP-A,CXCR16,t-HCY and D-dimer levels,and inversely proportional to DBIL,RHI and MPO values（P〈0.05）.Conclusions：Angptl2level is significantly abnormal in Type 2diabetes patients with carotid plaque.It has direct correlation with plaque nature-related indexes,and is the reliable index to judge patients＇ condition and predict the outcome.