阿托伐他汀钙、苯磺酸氨氯地平联合护理干预对原发性高血压颈动脉硬化的影响

Effects of atorvastatin calcium,amlodipine combined with nursing intervention on carotid atherosclerosis in patients with primary hypertension

目的：探讨阿托伐他汀钙、苯磺酸氨氯地平联合护理干预对原发性高血压颈动脉硬化的影响。方法：选取2014年12月～2015年12月收治的70例原发性高血压合并颈动脉硬化患者为研究对象,随机分为观察组和对照组;两组均口服阿托伐他汀钙20mg/次,1次/晚,苯磺酸氨氯地平5mg/次,1次/d,2周后血压未降至140/90mmHg以下者,剂量增加至10mg/次,两组用药周期均为6个月;在以上治疗基础上,对照组给予常规护理,观察组给予综合护理干预,观察治疗前后血压、血脂包括甘油三酯（TG）、胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）变化,彩色超声诊断仪测定颈动脉内膜中层厚度（IMT）及斑块数。结果：治疗后观察组收缩压、舒张压下降优于对照组,差异有统计学意义（均P〈0.05）;治疗后,观察组TC、LDL-C降低优于对照组,差异有统计学意义（均P〈0.05）;而TG、HDL-C与治疗前比较差异无统计学意义,两组比较差异无统计学意义（均P〉0.05）;治疗后观察组IMT及斑块数低于对照组,差异有统计学意义（均P〈0.05）。结论：阿托伐他汀钙、苯磺酸氨氯地平联合应用,可起到协同作用,有效调节血脂,保护血管内皮细胞功能,缩小颈IMT,临床联合护理干预能有效提高原发性高血压颈动脉硬化患者的临床治疗效果。

Objective：To explore the effects of atorvastatin calcium,amlodipine combined with nursing intervention on the carotid atherosclerosis in patients with primary hypertension.Methods：A total of 70 patients with primary hypertension merged with carotid atherosclerosis who were admitted in our hospital from December,2014 to December,2015 were included in the study and randomized into the observation group and the control group.The patients in the two groups were orally administered with atorvastatin calcium,20 mg/time,1time/night,and amlodipine,5 mg/time,1time/d.For patients whose blood pressure not reducing to 140/90 mmHg after 2weeks,the dosage was increased to 10mg/time.Six-month treatment was regarded as one course.On this basis,the patients in the control group were given the routine nursing,while the patients in the observation group were given the comprehensive nursing interventions.The levels of blood pressure,TG,TC,LDL-C,and HDL-C before and after treatment in the two groups were detected.The color ultrasonic diagnostic apparatus was used to measure IMT and plaque number.Results：After treatment,the reduced degree of SBP and DBP in the observation group was significantly superior to that in the control group（P〈0.05）.After treatment,the reduced degree of TC and LDL-C in the observation group was significantly superior to that in the control group（P〈0.05）,while TG and HDL-C levels were not significantly different from those before treatment,and the difference betweent the two groups was not statistically significant（P〈0.05）.After treatment,IMT and plaque number in the observation group were significantly lower than those in the control group（P〈0.05）.Conclusions：The combined application of atorvastatin calcium and amlodipine can play a synergistic effect,effectively regulate the serum lipid,protect the vascular endothelial cell function,and shrink the cervical IMT.Combined with nursing intervention,it can effectively enhance the clinical therapeutic effect in patients with primary hypertension merged with carotid atherosclerosis.