围绝经期妇女抑郁症状综合干预治疗的临床研究

Clinical Study on Comprehensive Intervention Therapy of Depression in Perimenopausal Women

目的:探讨围绝经期妇女抑郁症状综合干预治疗的临床疗效。方法:选取2013年6月-2014年6月本院妇科门诊和住院部收治的围绝经期妇女386例作为研究对象,对其进行一般问卷调查、应用改良Kupermann评分量表及Zung抑郁评分量表评分标准进行评估,筛选出围绝经期综合征伴发抑郁症状的妇女96例(24.87%),随机分为A、B、C三组治疗,每组32例。A组给予谷维素20 mg+维生素B6 20 mg,3次/d;B组给予替勃龙2.5 mg,1次/d;C组在B组的基础上给予心理健康治疗,重度抑郁症状者给予黛力新2片/d,早、中各1片,观察并比较三组的治疗效果、治疗前后围绝经期综合征及抑郁症状改善情况。结果:治疗后,A、B、C三组改良Kupermann减分率分别为22.88%、65.35%及73.65%,Zung减分率分别为20.56%、65.44%及78.33%,比较差异均有统计学意义(P<0.05);A、B、C组抗抑郁治疗有效率分别为34.4%、87.5%及93.8%,比较差异均有统计学意义(P<0.05);A、B、C组改善围绝经期症状总有效率分别为68.75%、90.62%及96.88%,比较差异均有统计学意义(P<0.05)。结论:围绝经期伴抑郁症状的妇女给予替勃龙加心理治疗及抗郁治疗具有较好的效果。

Objective：To explore the clinical effect of comprehensive intervention on depression symptoms in perimenopausal women.Method：From June 2013 to June 2014,386 perimenopausal women in our hospital gynaecology outpatient service and inpatient department were selected as the research objects,the general questionnaire,modified Kupermann rating scale and Zung depression rating scale were used to evaluate the scores,96（24.87%） women with menopausal syndrome associated with depressive symptoms were elected,they were divided into the A,B and C group,each group had 32 cases.A group was given Oryzanol 20 mg ＋ Vitamin B6 20 mg,three times a day.B group was treated with Tibolone 2.5 mg,one time a day.C group received mental health treatment on basis of B group,and severe depressive symptoms were given Deanxit treatment,two pieces a day,one piece on morning and afternoon,the therapeutic effect,improvement of menopausal syndrome and depression symptoms before and after treatment of three groups were observed and compared.Result：After treatment,A,B and C three groups improved Kupermann reduction rate was respectively 22.88%,65.35% and 73.65%,the reduction rate of Zung was respectively 20.56%,65.44% and 78.33%,the differences were statistically significant（P〈0.05）.The effective rate of anti-depression treatment was respectively 34.40%,87.50% and 93.80%,the differences were statistically significant（P〈0.05）. The total effective rate of improving menopausal symptoms was respectively 68.75%,90.62% and 96.88% in three groups,the differences were statistically significant（P〈0.05）.Conclusion：Perimenopausal women with depression symptoms has good curative effect of tibolone plus psychotherapy and antidepressant treatment.