慢性阻塞性肺疾病急性加重合并肺栓塞的临床特点与影响因素

Clinical Characteristics and Risk Factors of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Embolism

目的:评价慢性阻塞性肺疾病急性加重合并肺栓塞的临床特点与影响因素。方法:选取2013年1月-2015年8月本院收治的慢性阻塞性肺疾病急性加重合并肺栓塞患者50例作为合并肺栓塞组,另取同期收治的单纯慢性阻塞性肺疾病急性加重期患者50例作为未合并肺栓塞组,比较两组患者的D-二聚体检出值和慢性阻塞性肺疾病急性加重合并肺栓塞的影响因素。结果:合并肺栓塞组患者D-二聚体检出值为(760.0±50.0)μg/L,明显高于未合并肺栓塞组的(250.0±30.0)μg/L,比较差异有统计学意义(P<0.05);卧床时间≥7 d、双下肢不等粗≥1 cm及存在深静脉血栓是慢性阻塞性肺疾病急性加重合并肺栓塞的影响因素。结论:慢性阻塞性肺疾病急性加重合并肺栓塞患者临床特点以卧床时间≥7 d,双下肢不等粗≥1.0 cm及深静脉血栓为主,D-二聚体水平异常升高是合并肺栓塞的影响因素,可供临床重视。

Objective：To evaluate the clinical characteristics and risk factors of acute exacerbation of chronic obstructive pulmonary disease complicated with pulmonary embolism.Method：From January 2013 to August 2015,50 patients with acute exacerbation of chronic obstructive pulmonary disease complicated with pulmonary embolism in our hospital were selected as the combined pulmonary embolism group,another 50 patients with acute exacerbation of chronic obstructive pulmonary disease were selected as the not pulmonary embolism group in the same period.D-dimer detection value and impact factors of acute exacerbation of chronic obstructive pulmonary disease complicated with pulmonary embolism of two groups were compared.Result：D-dimer detection value in the combined pulmonary embolism group was（760.0±50.0） μg/L,higher than（250.0±30.0） μg/L of the not pulmonary embolism group,the difference was statistically significant（P〈0.05）.The time in bed≥7 days,double lower limbs coarse≥1 cm and deep vein thrombosis were the influence factors of pulmonary embolism in patients with acute exacerbation of chronic obstructive pulmonary disease.Conclusion：The clinical characteristics of acute exacerbation of chronic obstructive pulmonary disease complicated with pulmonary embolism are time in bed for more than 7 d,double lower limbs unequal diameter greater than 1 cm and deep vein thrombosis,D-dimer levels abnormal increase is the high risk factors of combined with pulmonary embolism,it can be used for clinical attention.