植物雌激素与乳腺癌发病发展的研究进展

Research Progress of Phytoestrogen in Incidence and Development of Breast Cancer

总结植物雌激素(phytoestrogen,PE)在乳腺癌发病、发展过程中的研究进展。应用Medline、Embase、CNKI及VIP数据库检索"植物雌激素、乳腺癌"相关基础临床试验流行病学调查。PE作为非甾体结构的雌激素类似物,能够与雌激素受体结合产生作用。目前研究主要集中于PE通过雌激素受体对乳腺癌细胞的增殖、凋亡、自噬、周期的影响和信号传导通路的研究,体外实验PE有抑制乳腺癌细胞增殖、促进凋亡、自噬的作用,但是对转移的作用不明确,可通过PI3K/AKT和ROS/p38MAPK途径诱导凋亡,PE与ER结合或调整ERα/ERβ达到抑制乳腺癌细胞的作用,流行病学调查未发现PE对人体有害,鲜有临床报道。因此,本文对PE对乳腺癌的研究进展进行总结分析,旨在为乳腺肿瘤患者治疗提供新方向。植物雌激素有希望成为乳腺肿瘤患者治疗的新方向。

The research progress of phytoestrogen（PE） in the pathogenesis and development of breast cancer were Summarized.The basic, clinical experiments and epidemiological investigation of PE and breast cancer was carried out by searching Medline,Pub Med, CNKI and VIP. As a estrogen analogues without steroidal structure, PE can combine with estrogen receptor and emits its effects In recent years, the studies mainly focused on the effects of estrogen receptor on the proliferation, apoptosis, autophagy, and signal transduction pathway of ER positive breast cancer. PE can inhibit the proliferation of breast cancer cells, promote apoptosis and autophagy in vitro, but the effect on metastasis is not clear. Apoptosis can be induced by PI3K/AKT and ROS/p38 MAPK pathway. PE can inhibit breast cancer by combining with estrogen receptor or regulating the rate of ERα/ERβ. No harmful effect is found in epidemiological investigations. However, the clinical reports on PE treating breast cancer were rare. Therefore this article summarized the research progress of PE to breast cancer. It aims to provide a new direction for the treatment of breast cancer.