定喘汤加减联合孟鲁司特钠治疗小儿咳嗽变异性哮喘的临床研究

The Clinical Observation of Dingchuan Decoction Combined with Montelukast Sodium in Children with Cough Variant Asthma

目的:探讨定喘汤加减联合孟鲁司特钠治疗小儿咳嗽变异性哮喘的临床疗效。方法:选取我院2012年1月至2014年1月收治的小儿咳嗽变异性哮喘患儿90例为研究对象,并随机分为对照组和观察组各45例。对照组采用孟鲁司特钠治疗,观察组采用孟鲁司特钠联合定喘汤加减治疗,比较两组患儿的治疗效果、控制起效时间、肺功能、中医证候积分、不良反应和复发情况。结果:观察组的治疗效果、起效时间、症状完全消失时间、复发率、肺功能指标和中医症候积分均优于对照组,差异有统计学意义(P<0.05),且观察组不良反应发生率低于对照组。结论:定喘汤加减联合孟鲁司特钠治疗小儿咳嗽变异性哮喘疗效较好,且安全性高,值得临床推广。

Objective： To investigate the clinical effect of Dingchuan decoction combined with montelukast sodium on children with cough variant asthma. Methods： Children with cough variant asthma in our hospital from Jan 2012 to Jan 2014 were selected and divided into control group and observation group,45 cases in each group. Children in the control group were treated with montelukast sodium,while children in observation group were treated with Dingchuan decoction combined with montelukast sodium. Treatment effect,control onset time,lung function,recurrence rate,symptom scores and adverse reactions of two groups were compared. Results： Treatment effect,control onset time,symptoms disappeared completely time,recurrence rate,lung function,symptom scores of observation group were better than those of control group,the differences were statistically significant（ P0.05）. And the incidence of adverse reactions in observation group was lower than that of the control group,the difference was statistically significant（ P 0. 05）. Conclusion： The treatment of Dingchuan decoction combined with montelukast sodium on children with cough variant asthma is effective and safe,it is worthy of promotion.