2014年我院儿科门诊超说明书用药情况调查

The Survey of Off-Label Drug Use Prescriptions in Pediatric Outpatient Department in 2014

目的:回顾性分析广州市妇女儿童医疗中心2014年儿科门诊超说明书用药情况,为规范超说明书用药提供参考。方法:分层随机抽取我院2014年1-12月儿科专科门诊处方,根据药品说明书,分析超说明书用药类型以及超说明书用药与年龄、科室、药品种类的关系。结果:共抽取2 366张处方,分析用药医嘱7 060条。按处方数目、用药医嘱条数、药品种类统计,超说明书用药统计结果分别为1 835张(77.56%)、3 651条(51.71%)和338种(80.48%)。超说明书用药类型主要是未提及儿童用药信息(34.76%)和超适应证(27.57%);超说明书用药年龄段主要在新生儿期(56.94%)和学龄前期(54.11%);超说明书用药科室主要在心血管科(68.97%)和肾内科(53.58%);超说明书用药药品种类主要是泌尿系统和生殖系统用药(97.66%)以及心血管系统用药(93.01%)。结论:我院儿科专科门诊超说明书用药情况普遍,需要进一步规范超说明书用药行为,促进儿童合理用药。

Objective： Retrospectively investigate the off-label drug use prescriptions in pediatrics outpatient department of Guangzhou Women and Children ＇s Medical Center in 2014,so as to provide reference for standardizing off-label drug use. Methods： The prescriptions of pediatrics outpatient department were randomly selected from January to December in 2014. According to the drug instruction,the off-label drug use was analyzed in types of off-label use and its relationships with different age groups,outpatient departments and categories of medicine. Results： A total of 2,366 prescriptions were selected,involving 7,060 medical orders. Of all sample prescriptions,the statistical results of off-label drug use were 1,835 prescriptions（ 77.56%）,3,651 medical orders（ 51.71%）and 338 kinds of drug categories（ 80. 48%）. The main types of off-label drug use were ＂without child medication information ＂（ 34. 76%） and＂out of indications＂（ 27. 57%）. The rate in different age groups were mainly infants（ 56. 94%） and preschool（ 54. 11%）. The main departments were cardiology（ 68.97%） and nephrology（ 53.58%）. The main drug categories were urinary and reproductive system drugs（ 97.66%） and cardiovascular system drugs（ 93.01%）. Conclusion： The off-label drug use is widespread in pediatrics outpatient department. It is necessary to standard off-label drug use to improve children rational drug use.