老年冠心病患者心血管疾病危险因素与冠状动脉造影病变程度的相关性研究

Correlation research of lesion degree of coronary angiography and cardiovascular risk factor in elderly patients with coronary heart disease

目的探讨老年冠心病患者心血管疾病危险因素与冠状动脉造影病变程度的相关性。方法选取2013年1月~2015年6月在本院进行冠状动脉造影的4799例老年住院患者作为研究对象,确诊为冠心病者3589例,占总病例数的74.79%,其中男性2188例,女性1401例。采用单因素方差分析和多因素Logistic回归分析对老年冠心病患者心血管疾病危险因素与冠状动脉造影病变程度的相关性进行分析。结果单个危险因素分析结果显示,年龄、性别、高血压、2型糖尿病、吸烟、高TC、高LDL-C和低HDL-C与冠状动脉病变的支数存在相关性（P〈0.05）。Logistic回归分析显示,年龄、性别、高血压、2型糖尿病、高TC以及吸烟为冠心病的独立危险因素（P〈0.05）,其中2型糖尿病是最为显著的独立危险因素（P〈0.05）。按性别进行分组后的Logistic回归分析显示,在男性中,2型糖尿病仍为冠心病的显著独立危险因素（P〈0.05）;在女性中,2型糖尿病、高血压和吸烟为冠心病的独立危险因素（P〈0.05）。结论 2型糖尿病是老年冠心病患者心血管疾病的危险因素,其在女性组中更为突出,吸烟、高血压病、高TC和年龄亦不可忽视。

Objective To explore the correlation of lesion degree of coronary angiography and cardiovascular risk factor in elderly patients with coronary heart disease. Methods 4799 elderly patients underwent coronary angiography in our hospital from January 2013 to June 2015 were selected as the research group,3589 cases of them were diagnosed as coronary heart disease,accounted for 74.79% in the total number,included 2188 male patients and 1401 female patients.The correlation of lesion degree of coronary angiography and cardiovascular risk factors in elderly patients was analyzed with one-way analysis of variance and multivariate Logistic regression analysis. Results Single risk factor analysis showed that the age,sex,hypertension,type 2 diabetes,smoking,high TC,high LDL-C and low HDL-C were correlated with the count of coronary artery disease（P〈0.05）.Logistic regression analysis showed that the age,sex,hypertension,type2 diabetes,high TC and smoking were independent risk factors for coronary heart disease（P〈0.05）,among them,type 2diabetes was the most significant independent risk factor（P〈0.05）.After grouped by gender,Logistic regression analysis showed that type 2 diabetes remained a significant independent risk factor for coronary heart disease in men（P〈0.05）,type 2 diabetes,hypertension,and smoking were independent risk factors for coronary heart disease in women（P〈0.05）.Conclusion Type 2 diabetes is a risk factor for cardiovascular disease in elderly patients with coronary heart disease,more prominent in the female group,smoking,hypertension,high TC and age should not be ignored.