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前列腺干细胞研究进展

Research Progress on Prostate Stem Cells
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摘要 干细胞是一种具有自我复制能力的多潜能细胞,具备多向分化潜能、自我更新、高度增殖的特性,具备再生各类人体器官以及人体的潜在能力,被医学界戏称为"全能细胞"。目前逐渐发现它在许多疾病的发生和治疗中发挥重大作用。近年研究发现前列腺内一样地存在着前列腺干细胞,在特定的环境中可以分化发育为前列腺组织,并与前列腺某些疾病有关。本文就有关前列腺干细胞相关文献研究进行综述。 Stem cells are a kind of pluripotent cells which can self-replicate, with characteristics of multilineage differentiation potential, self-renewal, and highly proliferation; stem cells with the potential function that regeneration of vatious tissues and organs and the body's under certain conditions, so they gain the ninckname "totipotent cell" by the medical field. Now we gradually found that they had played an important role in the occurrence and treatment of many diseases. Prostate stem cells have been found in prostate in recent years, they can be for prostate tissue differentiation development under certain conditions, and have something to do with some prostatic diseases. This review focuses on the latest progress in the field of prostate stem cells.
出处 《湖南中医药大学学报》 CAS 2016年第4期79-83,共5页 Journal of Hunan University of Chinese Medicine
基金 国家自然科学基金项目资助(81173264) 湖南省教育厅中医外科重点学科资助
关键词 干细胞 前列腺 表面标志物 stem cells prostate surface markers
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  • 1Tsujimura A, Koikawa Y, Salm S, et al. Proximal location of mouse prostate epithelial stem cells; A model of prostate homestasis[J]. J cell Biol,2005,157(7):1257-1265.
  • 2Cunha GR, Lung B. The possible influence of temporal factors in androgenic respongsiveness of urogenital tissue recombinants from wild-type and androgen -insensitive (Tfm)mice[J]. J Exp Zoology,1978,205(2):181-193.
  • 3Isaacs JT, Coffey DS. Etiology and isease process of benign prostatic hyperplasia[J]. Prostate Suppl,1989,2:33-50.
  • 4Wang ZA, Mitriofanova A, Bergren SK, et al. Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer hetergeneity[J].Nat Cell Biol,2013,15:274-283.
  • 5Lu TL, Huang YF, You LR, et al. Conditionally ablated ptenin prostate basal cells promotes basal-to-luminal differentiation and causes invasive peostate cancer in mice[J]. Am J Pathol,2013,182:975-991.
  • 6De Marzo AM, Meeker AK, Epsrein JI, et al. prostate stem cell compartments: Expression of the cell cycle inhibitor p27kip1 in nomal, hyperplastic and neoplastic cells[J]. Am J Pathol,1998,153(3):911-919.
  • 7Xin L,Lawson DA, Witte ON. The Sca-1 cell surface marker enriches for a prostate -regenerating cell subpopulation that can initiate prostate tumorigenesis[J]. Proc Natl Acad Sci USA,2005,102(20):6942-6947.
  • 8Burger PE, Xiong X, Coetzee S, et al. Sca-1 expression identifies stem cells in the proximal region of prostatic tissue[J]. Proc Natl Acad Sci USA,2005,102(20):7180-7185.
  • 9Jiao J, Hindoyan A, Wang S, et al. Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells[J]. PloS One,2012,7:e42564.
  • 10Collis AT, Habib FK, Maitland NJ, et al. Identification and isolation of human prostatic epithelial stem cells[J]. J Cell Sci,2004,117:3539-3545.

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