昌都锦鸡儿化学成分研究

Chemical Constituents from Caragana changduensis

目的:研究昌都锦鸡儿根茎木质部心材的化学成分。方法:采用多种柱色谱分离技术进行分离纯化,根据化合物的波谱数据和理化性质进行结构鉴定。结果:从昌都锦鸡儿根茎木质部心材中分离纯化得到10个化合物,分别鉴定为:苦参素(1)、(6aR,11aR)-3-羟基-4,9-二甲氧基紫檀烷(2)、(-)-4-methoxymaackiain(3)、(-)-homopterocarpin(4)、2,4-二甲氧基苯甲酸(5)、2-甲氧基-4-乙氧基苯甲酸(6)、3-乙酰基齐墩果酸(7)、7-羟基-2,3-二甲基色原酮(8)、甘草素(9)、β-谷甾醇(10)。结论:其中,化合物1、3、5、7、8为首次从该属植物中分离得到,所有化合物均为首次从该植物中分离得到。

Objective： To study the chemical constituents of the red heartwood of the stems and roots of Caragana changduensis. Methods： The chemical constituents were isolated and purified by means of several column chromatographic techniques,and their structures were determined by spectroscopic methods. Results： Ten compounds were isolated and identified as kushenin（ 1）,（ 6aR,11aR）-3-hydroxy-4,9-dimethoxy-pterocarpan（ 2）,（-）-4-methoxymaackiain（ 3）,（-）-homopterocarpin（ 4）,2,4-dimethoxybenzoic acid（ 5）,2-methoxy-4-ethoxybenzoic acid（ 6）,3-acetyl-oleanolic acid（ 7）,7-hydroxy-2,3-dimethylchromone（ 8）,liquiritigenin（ 9）,and β-sitosterol（ 10）. Conclusion： Compounds 1,3,5,7,and 8 are obtained from this genus for the first time. All the compounds are obtained from this plant for the first time.