草血竭化学成分研究

Chemical Constituents from Polygonum paleaceum

目的:对草血竭的化学成分进行分离及鉴定。方法:采用90%乙醇回流提取,利用硅胶、Sephadex LH-20、大孔树脂等柱色谱方法进行分离纯化,采用质谱、核磁共振等波谱方法对分得的化合物进行化学结构鉴定。结果:从草血竭乙醇提取物中分离得到10个化合物,分别鉴定为:绿原酸乙酯(1)、绿原酸甲酯(2)、山柰酚-3-O-α-L-吡喃鼠李糖苷(3)、(-)-表儿茶素(4)、paleaceolactoside(5)、原儿茶酸(6)、山柰酚(7)、没食子酸(8)、绿原酸(9)、异槲皮苷(10)。结论:其中,化合物1、3、6、7、10为首次从该植物中分离得到。

Objective： To isolate and identify the chemical constituents from Polygonum paleaceum. Methods： Chemical constituents were isolated and purified by column chromatography on silica gel,Sephadex HL-20 and macroporous resin etc. The chemical structures were identified by MS,NMR and spectral analysis. Results： Ten compounds were isolated and their structures were elucidated as ethyl chlorogenate（ 1）,methyl chlorogenate（ 2）,kaempferol-3-O-α-L-rhamnopyranoside（ 3）,（-）-epicatechin（ 4）,paleaceolactoside（ 5）,protocatechuic acid（ 6）,kaempferol（ 7）,gallic acid（ 8）,chlorogenic acid（ 9） and isoquercitrin（ 10）. Conclusion： Compounds 1,3,6,7 and 10 are isolated from this plant for the first time.