凝血四项与D-二聚体在产前检测中的临床价值

D-dimer coagulation and clinical value in prenatal detection

目的分析凝血四项与D-二聚体在产前检测中的临床价值。方法选择商丘市妇幼保健院2013年5月—2014年5月收治的65例晚期妊娠合并妊娠高血压疾病的孕妇设为观察A组,选择同期67例正常晚期妊娠孕妇设为观察B组,再选同期50例门诊体检非妊娠健康妇女作为对照组,分别给予凝血四项与D-二聚体检查。观察三组患者D-二聚体水平与凝血酶原时间(PT)、凝血活酶时间(TT)、活化部分凝血酶时间(APTT)、纤维蛋白原含量(FIB)凝血四项指标。结果观察A组的PT与APTT水平最低,FIB水平最高,其次是观察B组,对照组PT与APTT水平最高,FIB水平最低,三组间的比较差异具有统计学意义(P<0.05);3组TT水平比较无明显的统计学差异(P>0.05)。结论正常妊娠妇女及妊娠高血压疾病妇女的血液均为高凝状态,产前实施凝血四项与D-二聚体联合动态监测,能有效预防产后出血或其他血栓疾病,具有明确的临床价值。

Objective To analyze the D- dimer coagulation and clinical value in prenatal detection. Methods In Shangqiu Maternity and Child Care hospital in May 2013- May 2014 were treated 65 cases of late pregnancy with gestational hypertension in pregnant women to observe A group,choose the same period 67 cases of normal late pregnant women observation group B,50- year re- election Outpatient medical nonpregnant healthy women as a control group were given blood clotting and D- dimer. Observe the three groups D- dimer levels and prothrombin time（ PT）,thromboplastin time（ TT）,activated partial thromboplastin time（ APTT）,fibrinogen（ FIB） Coagulation indicators. Results PT and APTT level A group of minimum,maximum FIB level,followed by the observation group B,group PT and APTT highest level,FIB lowest level,the difference among the three groups was significant（ P〈0. 05）; 3 group TT There was no statistically significant difference（ P〈0. 05） level. Conclusion Normal pregnant women and women of hypertensive disorders of pregnancy are high blood coagulation status,prenatal implementation of coagulation and D-dimer dynamic monitoring,can effectively prevent postpartum hemorrhage or other thrombotic diseases,with a clear clinical value.