血清糖类抗原125、胆碱酯酶、前白蛋白与肝硬化患者肝功能关系研究

The Study on the Relationships between the Serum Carbohydrate Antigen 125,Cholinesterase,Prealbumin Levels and the Liver Function of Patients with Liver Cirrhosis

目的探讨血清糖类抗原125(CA125)、胆碱酯酶(Ch E)、前白蛋白(PA)与肝硬化患者肝功能关系。方法选取2013年7月至2014年12月在我院住院的56例肝硬化患者及对照组20例体检正常者,检测CA125、Ch E、PA水平。56例患者中,根据Child-Pugh肝功能分级,A级25例,B级19例,C级12例;有腹水33例,无腹水23例。结果肝硬化患者血清CA125明显高于对照组,Ch E、PA明显低于对照组(P<0.05);有腹水组与无腹水组比较,血清CA125明显增高(P<0.05),Ch E、PA明显降低(P<0.05);Child-Pugh B级组与A级组比较、C级组与B级组比较,CA125明显增高,Ch E、PA明显降低(P<0.05);肝功能状态与血清CA125呈正相关(r=0.671,P<0.05),与Ch E、PA呈显著负相关(r=-0.592,P<0.05;r=-0.685,P<0.05)。结论肝硬化患者中,CA125、Ch E、PA与肝功能状态具有相关性,血清CA125还与腹水形成有关,可以作为反映肝功能状态的指标。

Objective To investigate the relationships between the serum carbohydrate antigen 125,cholinesterase,Prealbumin levels and the liver function of patients with liver cirrhosis. Methods The level of serum CA125,Ch E,PA were detected in 56 patients with liver cirrhosis,collected form our department between July2013-December 2014,20 normal group were as control. According to the Child-Pugh standards,56 liver cirrhosis patients were divided into three groups,grade A 25 cases,grade B 19 cases,grade 12 cases; There are 33 cases with ascites,23 cases without ascites. Results Serum CA125 in patients with cirrhosis is significantly higher than the control group,Ch E,PA significantly lower than the control group,difference has statistical significance（ P〈0. 05）; In the patients with ascites group,serum CA125 levels were significantly higher（ P〈0. 05）,serum Ch E,PA decreased obviously（ P〈0. 05）; Child-Pugh class B group compared with class A group,the CA125 were significantly higher,and the Ch E,PA were lower（ P〈0. 05）; Child-Pugh C group compared with class A and class B group,the CA125 were significantly higher,and the Ch E,PA were lower（ P〈0. 05）; There were Positive correlation between serum levels of CA125 and liver function status（ r = 0. 671,P〈0. 05）,and there were negative correlation between serum Ch E,PA and liver function status（ r =- 0. 592,P〈0. 05 and r =- 0. 685,P〈0. 05）. Conclusion In patients with liver cirrhosis,liver function status were associated with CA125,Ch E,PA,serum CA125 is also associated with ascites formation,they can be as an indicator reflect the state of the liver function.