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重视凝血酶在肾间质纤维化中的地位及中医虫类药的干预作用 被引量:8

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摘要 慢性肾脏病(chronic kidney disease,CKD)患病率在全球范围内呈持续增长趋势,2012年我国的一项调查研究发现中国慢性肾病发病率为10.8%[1],CKD已成为严重危害公众健康的议题。而肾小管间质病变较肾小球病变在慢性肾脏疾病进展中的意义更为重要[2],这显然已成为国内外学术界的共识,
作者 杨洪涛
出处 《中国中西医结合肾病杂志》 2016年第4期283-286,共4页 Chinese Journal of Integrated Traditional and Western Nephrology
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参考文献26

  • 1Zhang L, Wang F, Wang L, et al. Prevalence of chronic kidney disease in China: a cross - sectional survey. Lancet, 2012,379 (9818) :815 -822.
  • 2Eitne R, Fran K, Floeg E, et al. Novel insights into renal fibrosis. Curr Opin Nephrol Hyper,2003,2 (3) :227 - 232.
  • 3Humphreys BD, Lin SL, Kobayashi A, et al. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J. Patho1,2010,176( 1 ) :85 - 97.
  • 4Koesters R, Kaissling B, Lehir M, et al. Tubular overexpression of transforming growth factor betal induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells. Am J Patho1,2010,177 (2) :632 - 643.
  • 5Inoue T,Umezawa A,Takenaka T,et al. The contribution of epi- thelial- mesenchymal transition to renal fibrosis differs among kidney disease models. Kidney Int,2015,87 ( 1 ) :233 -238.
  • 6Grandaliano G, Di Paolo S, Monno R, et al. Protease - activated receptor 1 and plasminogen activator inhibitor 1 expression in chronic allograft nephropathy:the role of coagulation and fibri- nolysis in renal graft fibrosis. Transplantation ,2001,72( 8 ) : 1437 - 1443.
  • 7Grandaliano G, Monno R, Ranieri E, et al. Regenerative and proinflammatory effects of thrombin on human proximal tubular cells. J Am Soc Nephrol,2000,11 (6) :1016 -1025.
  • 8陈香美,傅博,叶一舟,田巍,徐启河,王建中,韩玉珉.凝血酶介导肾小球系膜细胞细胞间粘附分子1表达上调及水蛭素的阻断作用[J].中华肾脏病杂志,1998,14(4):211-214. 被引量:39
  • 9Han Y, Guo J, Zheng Y, et al. Bivalirudin vs heparin with or without tirofiban during primary percutaneous coronary interven- tion in acute myocardial infarction: the BRIGHT randomized clinical trial. JAMA ,2015,313 ( 13 ) : 1336 - 1346.
  • 10Steg PG, van ' t Hof A, Hamm CW, et al. Bivalirudin started during emergency transport for primary PC1. N Engl J Med, 2013,369 (23) :2207 - 2217.

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