中西医结合治疗早期糖尿病肾病的疗效观察

Clinical Observation of the Combination of Traditional Chinese and Western Medicine in the Treatment of Early Diabetic Nephropathy

目的:探讨中西医结合治疗早期糖尿病肾病的临床疗效,为该类疾病的治疗提供参考。方法:选取早期糖尿病肾病患者90例,随机分为观察组和对照组各45例,对照组采用常规西医治疗,观察组在对照组的基础上加服补肾活血法中药治疗,比较两组患者的临床疗效、治疗前后肾功能指标和血糖、血脂指标的变化。结果:观察组患者的总有效率91.11%与对照组的62.22%比较,差异具有统计学意义(P<0.05);观察组患者治疗后24h尿蛋白定量、血浆白蛋白、血肌酐、尿素氮、空腹血糖、餐后2h血糖、总胆固醇、甘油三脂、低密度脂蛋白与治疗前及对照组治疗后比较,差异具有统计学意义(P<0.05);对照组患者治疗后上述各项指标与治疗前比较,差异不具有统计学意义(P>0.05);结论:中西医结合对早期糖尿病肾病的临床疗效优于单用西医的疗效,中西医结合能较好的改善早期糖尿病肾病患者的肾功能,对患者的血糖和血脂也具有较好的调节作用,值得临床合理选用。

Objective To explore the clinical effect of traditional Chinese and Western medicine in the treatment of early diabetic nephropathy to provide reference for the treatment of the disease. Methods 90 patients with early diabetic nephropathy diagnosed and treated in our hospital from June 2014 to May 2015 were selected and randomly divided into the observation group and the control group,each 45 cases. Patients in the control group were treated with conventional western medicine while patients in the observation group were treated withkidney nourishing and promoting blood circulation method of Chinese medicine treatment based on the treatment in the control group. The clinical curative effect,the changes of renal function indexes,blood glucose and blood lipid indexes of the patients in two groups before and after treatment before and after the treatment were compared. Results The total efficient rate of the observation group was 91. 11% and the difference was statistically significant,compared with 62. 22% in the control group（ P〈0. 05）. The urinary protein,serum albumin,serum creatinine,urea nitrogen,fasting blood glucose,blood glucose two hours after meal,total cholesterol,glycerin three greases,low density lipoprotein of the patients in the observation group after treatment were compared with those before treatment and the differences were statistically significant（ P〈0. 05）. The urinary protein,serum albumin,serum creatinine,urea nitrogen,fasting blood glucose,blood glucose two hours after meal,total cholesterol,glycerin three greases,low density lipoprotein of the patients in the control group after treatment were compared with those before treatment and the differences were not statistically significant（ P〉0. 05）. Patients in the control group after 24 hours The urinary protein,serum albumin,serum creatinine,urea nitrogen,fasting blood glucose,2 hour postprandial blood glucose and total cholesterol of the patients in the observation group were compared with those of patients in the control group and the differences were statistically significant（ P〈0. 05）. Conclusion Clinical effect of combination of traditional Chinese and Western Medicine on early diabetic nephropathy is better than that of single use of Western Medicine. The combination of traditional Chinese medicine and Western medicine can improve the renal function of patients with early diabetic nephropathy and has better regulatory effect on blood glucose and blood lipids of patients. This method is worth clinical rational use.