肺心病患者尿微量蛋白测定及其意义

Micro-Detection of Urinary Albumin in the Pxtients with Cor-Pulmonale and Its Significance

目的：探讨肺心病患者尿Ｂ２ 微球蛋白（ＵＢ２ － ＭＧ） 、尿白蛋白（ＵＡＩｂ） 、尿ＩｇＧ（ＵＩｇＧ）变化及其早期肾功能的损害。方法： 用放射免疫（ＲＩＡ） 法测定６４ 例肺心病患者ＵＢ２ － ＭＧ、ＵＩＡｂ 、ＵＩｇＧ以及血清肌酐（Ｃｒ） 、尿素（ＵＮ） 。结果：６４ 例肺心病患者Ｃｒ、ＵＮ均在正常范围内（ Ｐ＞ ０－０５） ， 而ＵＢ２ － ＭＧ、ＵＩＡｂ、ＵＩｇＧ 均明显升高且与对照组比较具有显著性差异（ Ｐ＜ ０－０５） 。结论：肺心病患者早期肾功能损害以肾小管重吸收功能降低为主，从而提示肺心病患者慎用肾毒性药物及肾代谢药物，对指导临床用药具有重要的意义。

Objective:To probe into the changes of urinary Uβ2-MG,UIAb and UIgG and the impairment of renal functions in cor-pulmonale.Method:Detecting urinary Uβ2-MG,urinary UIAb,urinary UIgG,sero-Cr and sero-UN by using RIA in 64 cases with cor-pulmonale. Results:The sero-Cr and sero-UN of 64 cases are normal (P<0.05),but their urinary Uβ2-MG,urinary UIAb and urinary UIgG are significantly higher than those in the control group (P<0.05).Conclusions: The early impairment of renal functions in the patients with cor-pulmonale fo cuses on the decrease of the reabsorption function of renal tubules.It should be very careful with the usage of nephrotoxic and renal metabolic drugs,which is of great importance in guiding the clinical usage of medicine.