“心脉龙”及山莨菪碱预防家兔实验性肺水肿的病理观察

Pathological Study of Xinmailong and Anisodamine on the Prevention of pulmonary Edema in Rabbits

大剂量静脉注射肾上腺素可造成家兔急性肺水肿，纯中药制剂“心脉龙”和山莨菪碱能有效地预防，且前者的预防效果更佳。本实验肺水肿组存活率为零，肺系数为７．５６±１．５５，镜下见肺泡壁毛细血管扩张，肺泡腔内充满水肿液；山莨菪碱预防组存活率为９０％，肺系数为５．２９±１．２４，镜下见肺泡壁毛细血管轻度扩张，肺泡腔内有少量水肿液；“心脉龙”预防组存活率为１００％，肺系数为４．８７±０．７９，镜下除见小灶性充血出血外，其余肺组织结构基本接近正常。

Acute Pulmonary edema was induced by Adrenaline(AD)administration in rabbits .This type of edema can be prevented by Xinmailong and Anisodamine the former being more effective. The pulmonary edema group all died within 10 minutes after AD injection, the survival rate being zero and the pulmonary index(PI) 7.56±1.55. The alveoli filled with fluid and ecchymosed hemorrhage could be seen under the light microscope (LM).The survival rate was 90% and PI was 5.29±1.24 in the Anisodamine Prevented group. Alittle fluid in alveoli was seen under LM. In the Xinmailong prevented group, the survival rate was 100% and the PI was 4.87± 0.79. The histologic structure was nearly normal.