集落刺激因子的临床应用研究进展

Advances in the Studies of Clinical Application of Colony Stimulating Factors

集落刺激因子（ＣＳＦ）自八十年代末期运用于临床以来，目前已在贫血、粒细胞减少、骨髓增生异常综合征（ＭＤＳ）、白血病、恶性淋巴瘤、放射病、骨髓移植（ＢＭＴ）等领域内得到广泛应用。在放射损伤中，ＣＳＦ有明显的预防和治疗作用。对其它疗法效果不佳的再生障碍性贫血、ＭＤＳ，ＣＳＦ疗效确切且副作用轻微。在ＢＭＴ方面，ＣＳＦ用于供髓者，可显著提高干细胞采集率，用于受者，可提高干细胞植活率，缩短造血恢复时间。

Since the late eighties, colony stimulating factors (CSF) have been used in the clinical practice. Now it is used for the treatment of anaemia, neutropenia, myelodysplastic syndrome (MDS),leukemia, malignant lymphoma, radiogenic, diseases , bone marrow transplantation (BMT) etc. For radiogenic injury, CSF has both protective and therapeutic effects. For aplastic anaemia and MDS, the therapeutic effects of CSF are definite , and its side-effects are mild. For BMT, after the administration of CSF, the stem cells in the donors’ marrow and peripheral blood can be increased significantly , and the functional recovery of the recipients’ bone marrow accelerated.