摘要
Ｃ（５７）ＢＬ／６Ｊ小鼠腹腔注射ＰＳＰ１００ｍｇ·ｋｇ（－１），连续１２ｄ，可明显促进小鼠Ｋ细胞ＡＤＣＣ活性，ＰＳＰ组Ｋ细胞毒指数（ＣＩ）比对照组升高５４．７％。在５ｍｇ／Ｌ～３２０ｍｇ／Ｌ浓度范围内，ＰＳＰ可促进体外培养的Ｃ（５７）ＢＬ／６Ｊ小鼠腹腔巨噬细胞ＡＤＣＣ活性，最适浓度为８０ｍｇ／Ｌ其ＣＩ值为对照孔的５．１４倍。
This paper reports the results of intraperitoneal(IP)100mg/kg of PSP to C57BL/6J mice for 12 days, which showed that PSP could significantly enhance the ADCC activity of K-cell in vivo, and that the cytotoxicity index(CI) of the K-cell of the PSP group increased by 54.7% as compared with the control group.PSP had remarkable effect on the promotion of the ADCC activity of the IP Mφ of the C57BL/6J mice in vitro in the concerntration ranging from 5ug/ml to 320ug/ml,the optimum concerntration of the PSP was 80ug/ml and its CI value was 4.19 times as much as that of the control pore.
基金
美国中华医学基金
