摘要
一过性心肌缺血时因能量的耗竭而导致的心肌细胞内钙超负荷是引起再灌注损伤的重要基础。钙拮抗剂阻滞钙通道,防止细胞内钙超负荷,并通过减少能量代谢,提高心肌抗缺血能力,有效地减轻心肌组织的再灌注损伤。
Injury of ischmic mycardium is calcium paradox. Calcium antagonists may reduce Ca2+ in the cells ischmic mycardium cell, and protect it effectively from reperfusion injury.
关键词
钙拮抗剂
再灌注损伤
Reperfusion injury
Calcium antagonist