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类风湿性关节炎患者免疫功能的研究 被引量:3

Study on Immunologic Function of patients With Rheumatoid Arithritis
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摘要 本文检测48例RA患者免疫学指标,结果表明:外周血T淋巴细胞亚群CD3细胞明显低于正常对照组(P<0.01),CD4细胞、CD4/CD8比值显著高于正常对照组(P<0.01),而CD8细胞与正常人相近(P>0.05),血清IgG、IgA、IgM、CRP、IL-2及SIL-2R显著高于正常对照组(P<0.01),提示RA患者细胞及体液免疫功能严重紊乱。 Immunologic functions were measured in 48 patients With heumatoid arithritis.The results showed that the serum IgG、IgA、IgM、CRP、IC-2,SIC-2R and subgroup of T-lymphocyte CD 4,CD 4/CD 8 were obviously higher(P<0.01)but CD 3 Werr much lowsr (P<0.01) than that of the control group.CD 8 is closely relatel to that of the control group.(P>0.05)It is suggested that there be severe functional disorder of cellular and humoral immunity in the body of patient with rheumatoid arithritis.
机构地区 解放军
出处 《大理学院学报(医学版)》 1997年第3期24-26,共3页
关键词 类风湿性关节炎 免疫球蛋白 白细胞介素2 Rheumatoid arithritis Immunoglobulin IC-2
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  • 1王锋,汪年松,晏春根.类风湿关节炎患者活动期血小板的活化功能[J].中国临床康复,2006,10(40):84-86. 被引量:12
  • 2Katy WA. Rheumatic Disease Diagnosis and Management [ M ]. Philadelphia : Lippihcott co, 1987:446.
  • 3Adhya S, Chakraborty. Serology and immunoglobulin profile in rheumatoid arthritis [J]. Indian Pathol Microbial ,1998,41 ( 1 ) :43.
  • 4Jonsson T, Steinsson K. Combined elevation of IgM and IgA rheumatoid factor has high diagnostic specificity for rheuma-toid arthritis [ J ]. Rheumatol Int, 1998,18 ( 3 ) : 119.
  • 5Katy WA.Rheumatic disease diagnosis and management,philadelphla:Lippihcott co,1987.446.
  • 6Oen K,Krzekotowska D.Growth and differentiation of B cells from patients with juvenilerheumatiod arthritis.Arthritis Rheum,1989,32:150.
  • 7Eberhardt KB,Truedsson L,Pettersson H,et al.Disease activity and joint damage progressionin early rheumatoid arthritis; relation to IgG,IgA,and IgM reheumatoid factor.Ann Rheum Dis,1990,49:906.
  • 8Gray S, R.enate EG, William JK ,et al.Molecular and Cellular mechanisms of joint destruction in rheumatoid arthritis; two cellular mechanisms explain joint destruction [J].Ann Rheum Dis, 1993 ; 52 (suppl) :39
  • 9Amett FC,Edworthy SM, Block DA, et al. The 1987 revised ARA criteria for rheumatoid arthritis (R.A)[J].Arthritis Rheum,1987;30(Suppl 17): 45
  • 10Adhya S, Chakraborty. Serology and immunoglobulin profile in rheumatoid arthritis [J].Indian Pathol Microbial, 1998; 41 (1):43

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