摘要
目的:观察β2微球蛋白(β2—MG)、白蛋白(Alb)、免疫球蛋白G(IgG)放射免疫测定(RIA),对早期糖尿病肾病(DN)的诊断价值。方法:对80例糖尿病患者分别进行尿常规蛋白定性、血尿素氮(BUN)、血肌酐(Cr)检测及血、尿β2—MG、尿Alb、IgGRIA测定。结果:β2—MG、Alb、IgGRIA敏感性明显高于传统检查(P<0.005);与正常组对照糖尿病人血、尿β2—MG、尿Alb、尿IgG明显升高(P<0.001)。结论:β2—MG、Alb、IgGRIA对于DN的诊断明显优于传统检查,建议作为DN的早期诊断指标。
Objective:To determine the value of β2MG,ALB,IgG RIA in the early diagnosis of diabetic nephropathyMethods:The routine urinalysis,serum urea(BUN) and serum creatintne(Cr) of 80 diabetic patients were measured by regular method,at the same time serum,urine β2microgiuobulin(β2MG),urine album(ALB) and urine immunoglobin G(IgG) were measured by radioimmunoassay(RIA)Results:the incidences of β2MG,AIb,IgG RLA were significantly higher than those of routine urinalysis,BUN,CrThe levels of serum,urine β2MG,Alb IgG of diabetic patients was obviously higher than those of the control groupConclusions:Diabetic patients are easy to be complicated with diabetic nephropathy(DN)β2MG,Alb,IgG RLA are better ways to diagnose DN than the traditional test,and it is proposed to be regarded as diagnostic index for early DN