NIDDM患者血管病变凝血及纤溶功能的研究

A Research of Blood Coagulation and Fibrinolysis in Patients with Vasculopathy of NIDDM

目的：探讨凝血及纤溶活性改变与糖尿病血管病变的关系。方法：采用有对照的横断面研究，分别检测糖尿病合并血管病变２９例、无血管病变２７例以及３０例健康成人的凝血及纤溶活性指标１２项，并进行血管病变的多因素分析。结果：糖尿病患者凝血活性增高，存在高凝状态，而纤溶活性下降，以上改变在血管病变组更为明显。

Objective:To explore the relatioship between blood coagulation,fibrinolysis and vasculopathy in NIDDM.Methods:Cross-sectional controlled trail and Stepwise Logistic regression were performed.The blood coagulation and fibrinolysis of the 56 patients,(29 with vasculopathy),and 30 heakthy adults were examined and analyzed.Result:NIDDM especially those with vasculopathy showed decreased fibrinolysis and increased coagulation activation.Conclusion:High blood coagulation and lower fibrinolysis activation may contribute to the etiology of NIDDM vasculor lesions.