舒他西林、氧氟沙星、氯霉素治疗伤寒128例疗效观察

A Comparative Study in the Treatment of 128 cases of Typhoid Feverwith Sulbactam-Ampicillin,Ofloxacin and Chloramphenicol

目的：评价三种抗菌素治疗伤寒的安全性和有效性。方法：将１２８例伤寒患者随机分为三组，分别予舒他西林３ｇ静滴，１次／日；氧氟沙星２００ｍｇ静滴，１次／日；氯霉素１ｇ静滴，１次／日。结果：总有效率舒他西林组为９７８％，氧氟沙星组为９２９％，氯霉素组为８０％。组间比较，舒他西林组与氯霉素组间有显著差异性，Ｐ＜００１。余两组间差异无显著性。副作用发生率：舒他西林组为４３％，氧氟沙星组为１４３％，氯霉素组为７５％。结论：舒他西林治疗伤寒疗效最好而副作用最少，可做为治疗伤寒的首选药物。

Objective:To evaluate the effectiveness and the safety of the three antibiotics in the treatment of typhoid fever.Methods:128 cases of patients with typhoid fever in the hospital were divided randomly into three groups.They were given 3g of Sulbactam-Ampicillin, 200mg of Ofloxacin and lg of Chloramphenicol by intravenous injection every day,respectively.Results:The effective rates of the drugs were 978%, 929% and 80% respectively.There is a significant difference between the Sulbactam-Ampicillin group and Chloramphenicol group in effective rates(P<001) and there is no marked difference between the other two groups(P>005). Their side-effect incidences are 43%, 143% and 75% respectively. Conclusion:It suggests that Sulbactam-Ampicillin has the best effect and safety in the three antibiotics in the treatment of typhoid fever and it can be used as the first selected drug in the treatment of typhoid fever.