顺铂腹腔灌注联合多西他赛静脉化疗方案在晚期卵巢癌患者中的应用效果比较

Application of intraperitoneal perfusion of cisplatin combined with intravenous injection of docetaxel in advanced ovarian cancer

目的探讨顺铂腹腔灌注联合多西他赛静脉化疗对卵巢癌晚期患者的治疗效果和不良反应。方法选取卵巢癌晚期患者98例作为研究对象,采用随机数字表法分为观察组和对照组各49例。观察组采用多西他赛静脉输注联合顺铂腹腔灌注治疗,对照组采用多西他赛和顺铂静脉滴注化疗,两组剂量相同,且均化疗6个周期。结果两组不良反应主要分为静脉化疗骨髓抑制和肝损伤,两组患者静脉化疗骨髓抑制发生情况比较,差异有统计学意义(P﹤0.05);两组患者部分缓解率比较,差异有统计学意义(P﹤0.05);观察组的临床有效率和临床受益率均高于对照组,差异有统计学意义(P﹤0.05)。结论采用顺铂腹腔灌注联合多西他赛静脉化疗的方式对晚期卵巢癌的患者进行化疗能够提高疗效,减轻患者痛苦。

Objective To study the therapeutic effect of intraperitoneal perfusion of cisplatin combined with intravenous injection of docetaxel in the treatment of advanced ovarian cancer and the adverse reactions. Method 98 patients with advanced ovarian cancer were enrolled in this study, who were randomized into study group or control group, with 49 patients in each. The study group was administered with intravenous injection of docetaxel and intraperitoneal perfu- sion of cisplatin, while the control group was given intravenous injection of docetaxel and cisplatin at the same dose level with the study group, for 6 cycles. Result The adverse reactions were mainly intravenous chemotherapy induced bone marrow suppression （BMS） and hepatic impairment, while the incidence of intravenous chemotherapy induced BMS in the two groups were significantly different （P〈0.05）; and the partial response rate of both groups were of statistically significant difference （P〈0.05）; the clinical response rate and clinical benefit rate of the study gxoup was significantly higher than that of the control group （P〈0.05）. Conclusion The regimen of intraperitoneal perfusion of cisplatin combined with intravenous injection of docetaxel may improve the curative effect, and help relieve the pain of patients.