结直肠癌患者胸苷酸磷酸化酶活性与XELOX新辅助化疗疗效的关系

The correlation between enzymatic activity of thymidine phosphorylase and the efficacy of XELOX NC in colorectal cancer patients

目的研究结直肠癌中胸苷酸磷酸化酶(TP)活性与XELOX新辅助化疗疗效之间的关系。方法收集64例采用XELOX方案化疗的结直肠癌患者临床资料,根据TP酶活性不同分为TP高酶活性组(32例)和TP低酶活性组(32例),统计两组患者的化疗效果以及术后5年生存期。结果 TP高酶活性组患者化疗后病灶减小程度高于TP低酶活性组,周围组织的浸润程度低于TP低酶活性组,同时患者的术后生存率亦高于TP低酶活性组,差异均具有统计学意义(P﹤0.05)。结论结直肠癌中胸苷酸磷酸化酶活性越高,XELOX化疗敏感性越高,化疗效果越好,预后相对优于TP酶活性低者。

Objective To study the correlation between thymidine phosphorylase （TP） and XELOX neoadjuvant chemotherapy. Method 64 cases of colorectal cancer patients who were administered with XELOX regimen were enrolled in this study, and were then stratified as either high TP group（n=32） or low TP group（n=32） by individual TP enzymatic activity, the efficacy and 5-year survival of both groups were analyzed. Result The TP lesions shrank more in the high TP group compared with that of the low TP group, besides, a less infiltration and a higher postoperative survival rate were observed in the low TP group, and all differences were of statistical significance （P〈0.05）. Conclusion TP enzymatic activity is higher, the XELOX is more sensitive, the effect of chemotherapy is better in colorectal cancer.