山楂消脂胶囊治疗多囊卵巢综合症胰岛素抵抗的疗效观察

Clinical observation on treating insulin resistance in PCOS patients with the Shanzha Xiaozhi capsules

目的:观察山楂消脂胶囊对多囊卵巢综合症(PCOS)患者胰岛素抵抗的临床疗效。方法:将100例PCOS患者随机分成治疗组和对照组,给予治疗组患者连续口服山楂消脂胶囊加二甲双胍片3个月,对照组则单纯连续口服二甲双胍片3个月进行治疗,然后对比其临床疗效。结果:经治疗后,两组的体重指数(BMI)、体脂分布指数(PBF)及腰臀比(WHR)均分别较治疗前下降,治疗组的BMI及WHR的下降程度较对照组明显,差异具有统计学意义(P<0.05);治疗组的空腹血糖(FPG)、空腹胰岛素(Fins)、餐后2h血糖、餐后2h胰岛素及胰岛素抵抗指数(HOMA-IR)均较治疗前明显下降,差异具有统计学意义(P<0.05);而对照组仅有FPG、Fins及HOMA-IR较治疗前明显下降,差异具有统计学意义(P<0.05);同时,治疗组的下降幅度较对照组明显,治疗效果明显优于对照组,差异具有统计学意义(P<0.05)。结论:山楂消脂胶囊能改善PCOS患者胰岛素抵抗程度,对PCOS患者的糖代谢异常具有良好的治疗效果,值得在临床推广。

Objective To observe effects of the Shanzha Xiaozhi capsules on insulin resistance in PCOS patients. Methods： 99patients were divided into the treatment group and the control group. The treatment group was given the Shanzha Xiaozhi capsules anddimethylbiguanide for 3 months, and the control group was given dimethylbiguanide for 3 months. Results： After treatment, BMI, PBFand WHR were improved in two groups. And improvement was better in the treatment group（P〈0.05）. In the treatment group, FPG, Fins,postprandial 2h plasma glucose, postprandial 2h insulin and HOMA-IR were better improved （P〈0.05）. In the control group, FPG, Finsand HOMA-IR were more decreased （P〈0.05）. The efficacy in the treatment group was better （P〈0.05）. Conclusion： The Shanzha Xiaozhicapsules can improve insulin resistance in PCOS patients, and is worthy of promotion.