益气活血法治疗慢性阻塞性肺疾病稳定期营养不良临床研究

A clinical study on treating malnutrition of COPD in stable period by the Yiqi Huoxue therapy

目的:观察益气活血法治疗慢性阻塞性肺疾病稳定期患者营养状况的疗效。方法:按纳入及排除标准,将72例患者随机分为观察组和对照组各36例。两组患者均给予西医常规标准化治疗,治疗组加服益气活血中药,以30d为治疗周期,观察患者治疗前后的理想体重百分比(BWI%)、肱三头肌皮褶厚度TSF、上臂围长MAC、血清白蛋白ALB、转铁蛋白TRF及微型营养评定表MNA等指标的变化情况。结果:两组治疗后,IBW%、ALB、TRF三个指标与治疗前比较,差异有统计学意义,但在改善TSF和MAC方面,差异均无统计学意义;而MNA的改善虽有统计学差异,但仍处于存在营养不良风险的范围。结论:益气活血中药能提高理想体重百分比,同时改善血清白蛋白和转铁蛋白含量及微量营养评分,由此笔者推测益气活血法能使该类患者营养不良情况得到改善,但其内在机制仍有待进一步研究探讨。

Objective To explore clinical effects of the Yiqi Huoxue therapy on malnutrition of chronic obstructive pulmonarydisease in stable period. Methods： 72 patients who met the standard were selected and divided into two groups, 36 cases in each. All thepatients were treated by standard scheme for 30 days, and the patients in the observed group received the Yiqi Huoxue therapy more.The change of indexes such as ideal body weight, triceps skinfold, mid-arm circumference, albumin （ALB）, the concentration of serumtransferrin, and the score of mini nutritional assessment were observed. Results： After the treatment, IBW%, ALB, TRF were improvedsignificantly, but TSF and MAC showed no change. The MNA score in the observed group was higher. However, the MNA score was in therange of risking for malnutrition. Conclusion： We inferred that the Yiqi Huoxue therapy can improve the nutritional status in patients withchronic obstructive pulmonary disease, but the internal mechanism remains to be further study.