疏肝健脾和胃汤治疗胃食管反流性病的近期和远期效果研究

A study on the short-term and long-term clinical effects of the Shugan Jianpi Hewei decoction on gastroesophageal reflux disease

目的:观察疏肝健脾和胃汤对肝胃郁热证胃食管反流性疾病患者的近期和远期临床疗效。方法:选取肝胃郁热证胃食管反流病患者78例,按照1∶1比例随机分为观察组和对照组。对照组患者给予兰索拉唑肠溶片。观察组患者给予疏肝健脾和胃汤。观察两组治疗8周后及随访6个月后的临床疗效及中医证候疗效。结果:两组治疗后临床疗效及中医证候疗效总积分均较治疗前有所下降(P<0.01)。治疗8周后,对照组临床疗效及中医证候疗效总积分均低于观察组(P<0.05,P<0.01)。随访6个月,观察组临床疗效及中医证候疗效总积分均低于对照组(P<0.01)。结论:西药控制GSRD病情近期疗效优于中药疏肝健脾和胃汤,而中医药治疗GSRD远期临床效果明显优于西药。

Objective To observe the short-term and long-term clinical efficacy of the Shugan Jianpi Hewei decoction on gastroesophageal reflux disease. Methods： 78 cases were randomly divided into the observation group and the control group according to the ratioof 1 ∶ 1.The control group was treated with Lansoprazole. The observation group was treated with the Shugan Jianpi Hewei decoction.Results： The total scores of clinical efficacy and TCM symptoms in two groups were decreased （P〈0.01）. In 8 weeks, the total scores ofclinical efficacy and TCM symptoms in the control group were lower （P〈0.01, P〈0.05）. In 6 months, the total scores of clinical efficacyand TCM symptoms in the observation group were lower （P〈0.05）. Conclusion： The short-term clinical efficacy of the western medicine isbetter, but the long-term clinical effect of TCM is better.