不同给药方法对白细胞介素2和α-干扰素致流感样不良反应的影响

Effects of Different Administration Method on Influenza-like Adverse Drug Reactions Induced by Int erleukin-2 and α-interferon

目的：探讨不同给药方法对白细胞介素2（IL-2）和α-干扰素（α-INF）致流感样不良反应发生率的影响。方法：选取南阳市中心医院患者20例,按随机数字表法用数字1~20表示,1~10为A组,11~20为B组,2组患者均应用IL-2 100万IU/支＋0.9%氯化钠注射液500 ml,1日1次,静脉注射;α-INF 300万IU/支,1日1次,肌肉注射,2种药物均为注射5 d停药2 d。A组采用1、3周传统给药方法,2、4周改良给药方法;B组采用1、3周改良给药方法,2、4周传统给药方法。观察不同给药方案对IL-2和α-INF致流感样不良反应发生率的影响。结果：传统给药方案共发生139次（占69.50%）流感样不良反应,改良给药方案患者共发生47例（占23.50%）,2组的差异有统计学意义（P〈0.05）;以2周为参考时间段,用药次数为75次,B组41例（占54.67%）患者发生次流感样不良反应,A组为13例（占17.33%）,2组的差异有统计学意义（P〈0.05）。结论：采用改良给药方法可有效减少流感样不良反应率,若是将2组给药方式结合,先给予传统给药方法然后给予改良给药方法,则对临床治疗帮助更大。

OBJECTIVE：To investigate different administration method on influenza-like adverse drug reactions induced by interleukin-2（IL-2） and α-interferon（α-INF）.METHODS：20 cases admitted into Nanyang Central Hospital were selected as the research objects with the number of 1-20 according to the random number table,and 1-10 were group A,11-20 was group B.Two group of patients were treated with IL-2 1 million IU / time ＋0.9% sodium chloride injection 500 ml,once a day,IV;α-INF 3 million IU / time,once a day,in intramuscular injection;two kinds of drugs were in 5 d of injection and 2 d of discontinuation.Group A received traditional administration method in the 1st and 3rd week,and improved administration method in the 2ed and 4th week;group B were given the improved administration method in the 1st and 3rd week,traditional administration method in the 2ed and 4th week.Effects of different administration method on incidence of influenza-like adverse drug reactions induced by IL-2 and α-INF were observed.RESULTS：139 cases（69.50%） of influenza-like adverse drug reactions occurred in the traditional method,while only 47 cases（23.50%） in the improved method,the difference was statistically significant（P 〈0.05）.To set two weeks as the reference time,during which 75 times of administration were given,there were41 cases（54.67%） of influenza-like adverse drug reactions in group B,13 cases（17.33%） in group A,thedifference was statistically significant（P 〈0.05）.CONCLUSIONS：The improved method can effectively reduce the incidence of influenza-like adverse drug reactions.If the traditional administration method combine with the improved administration method together,the clinical treatment efficacy would be improved.