2011—2013年北京市垂杨柳医院门诊抗抑郁药应用分析

Analysis on Application of Antidepressants in Beijing Chuiyangliu Hospital During 2011-2013

目的：了解北京市垂杨柳医院（以下简称＂我院＂）门诊抗抑郁药的应用现状,为临床合理用药提供依据。方法：回顾性分析我院门诊2011—2013年抗抑郁药的销售金额、用药频度（defined daily dose system,DDDs）和限定日费用（daily drug cost,DDC）等情况,并进行统计分析。结果：2011—2013年我院门诊抗抑郁药的销售金额呈逐年上升趋势,依次为133.68、157.60、176.11万元;用药以5-羟色胺再摄取抑制剂（selective serotonin reuptake inhibitor,SSRI）为主,3年中其DDDs分别为77.14、80.37、80.06。2011—2013年,帕罗西汀销售金额分别为75.51、92.88、99.90万元,DDDs为6.93,8.59,10.55,销售金额及DDDs一直居首位;DDC最高的为文拉法辛,其次为西酞普兰和帕罗西汀,最低的为阿米替林,仅为0.51元。我院门诊抗抑郁药应用病例数呈上升趋势,女性多于男性,男女比例1∶1.48;应用的年龄范围为17~101岁,平均年龄（57.29±16.09）岁,人数较多的年龄段为41~80岁。2011—2013年门诊科室抗抑郁药应用比例最高的为精防科门诊,分别为21.01%、35.03%、38.45%;其次是神经内科门诊,分别为8.10%、10.50%、13.02%。结论：SSRI已成为我院抗抑郁首选药,且帕罗西汀在SSRI类药物中的使用位居首位,且门诊抗抑郁药应用病例数呈上升趋势。

OBJECTIVE：To analyze the application status of antidepressants in Beijing Chuiyangliu Hospital（hereinafter referred to as ＂our hospital＂）,so as to provide basis for the rational drug use in clinic.METHODS：Consumption sum,defined daily dose system（DDDs） and daily drug cost（DDC） of antidepressants in the outpatient department of our hospital during 2011-2013 were analyzed statistically.RESULTS：The consumption sum of antidepressants in the outpatient department of our hospital during 2011-2013 increased year by year,were respectively133.68 ten thousand yuan,157.60 ten thousand yuan and 176.11 ten thousand yuan.SSRI was the main application drugs,and its DDDs for the recent three years were 77.14,80.37 and 80.06.During 2011-2013,the consumption sum of paroxetine were respectively 75.51,92.88 and 99.90 ten thousand yuan,DDDs were 6.93,8.59 and 10.55;both the consumption sum and DDDs of paroxetine took the lead.Meanwhile,DDC of venlaxine dominated the first place,followed by citalopram and paroxetine,and amitriptyline was lowest,only 0.51 yuan.The tendency of cases with antidepressants increased year by year,more females than males,and the ratio of male to female was 1∶ 1.48,the age range of application was 17-101 years old,the average age was（57.29 ± 16.09） years old,and 41-80 years old was the most.The highest application ratio of antidepressants was the psychiatric outpatient department during 2011-2013,were respectively 21.01%,35.03% and 38.45%;followed by neurology outpatient department,were respectively 8.10%,10.50% and 13.02%.CONCLUSIONS：SSRI has been regarded as the first choice of antidepressants,and the application of paroxetine dominates the first place of SSRI,and cases with the application of antidepressants in outpatient department are in an increase trend.