280例药品不良反应报告

Reports on 280 Cases of Adverse Drug Reactions

目的:了解镇江市第三人民医院(以下简称"我院")药品不良反应(adverse drug reaction,ADR)的发生特点及其引发的相关因素,促进临床合理用药。方法:对我院2010年1月—2015年5月收集的280例ADR报告进行统计分析。结果:280例临床ADR报告中,引起ADR最多的药物为抗微生物药(161例,占57.50%),其次为中药制剂(39例,13.93%)以及循环系统药(4例,1.43%);最常见的临床表现为皮肤及其附件损害(127例,占45.36%);给药途径以静脉给药发生率最高(192例,占68.58%),其次为全身性损害(65例,占23.21%)和消化系统损害(55例,19.64%)。严重的ADR有41例(占14.64%)。结论:ADR的发生与多种因素有关,医院应提高对ADR的关注度,加强ADR监测,完善ADR的事后警戒与控制防范制度,同时发挥临床药师的作用,开展ADR知识和安全用药宣传,进一步降低ADR的发生率,保障公众用药安全。

OBJECTIVE：To investigate the characteristics and the related factors of adverse drug reaction（ADR）in the Third People＇s Hospital of Zhenjiang（hereinafter referred to as ＂our hospital＂）,so as to promote the rational drug use in clinic.METHODS：Of the 280 cases of ADR reports,anti-microbial drugs took the lead that induced ADR（161 cases,57.50%）,followed by traditional Chinese preparation（39 cases,13.93%） and circulatory system drugs（4 cases,1.43%）.Lesions of skin and its appendants were most common clinical manifestations of ADR（127 cases,45.36%）.And the routes of administration in intravenous was the highest（192 cases,68.58%）,followed by systemic lesions（65 cases,23.21%） and digestive system damage（55 cases,19.64%）.There were 41 cases of severe ADR（14.64%）.CONCLUSIONS：The occurrence of ADR is related to various factors.It is necessary to attach more importance on ADR,strengthen ADR monitoring,improve the guardsystem of ADR,so as to ensure the medication safety in patients.