摘要
miRNA是一类非编码的小RNA,它主要利用碱基互补配对的方式与特异性靶基因信使RNA的3’-非翻译区结合,通过降解靶RNA或抑制蛋白质的翻译合成,从而实现对靶基因转录后水平的调控.放射治疗是治疗肿瘤的主要手段之一,肿瘤的辐射生物效应对其放疗效果至关重要,也是确定某肿瘤组织辐射敏感或辐射耐受的一个重要因素.研究证实,miRNAs通过影响DNA损伤修复、细胞周期检查点、凋亡、信号转导、肿瘤组织微环境等因素参与肿瘤放疗敏感性的调控,miRNAs为肿瘤放射治疗提供了新途径.
MiRNA is a small non-protein coding RNA that play an important role in gene regulation by targeting the 3'untranslated region of specific target gene mRNA,leading to the degradation of target RNA or inhibition of protein synthesis in post-transcriptional level.Radiation therapy is a main method for cancer treatment.Tumor radiation biological effect is critical in radiotherapy and a core determining factor of tumor radioresistance or radiosensitivity.Recent studies have demonstrated that miRNA can regulate tumor radiosensitivity by affecting DNA damage repair,cell cycle checkpoint,apoptosis,signal transduction pathways and tumor microenvironment etc.miRNA offer potential new approach to complement the radiotherapy for tumor treatment.
出处
《国际放射医学核医学杂志》
2016年第2期159-164,共6页
International Journal of Radiation Medicine and Nuclear Medicine
基金
加强中国生物剂量计研究项目(17092)
关键词
放射疗法
计算机辅助
辐射耐受性
微RNAs
MicroRNAs
Radiotherapy,computer-assisted
Radiation tolerance