小剂量美罗华联合重组人血小板生成素治疗难治性特发性血小板减少性紫癜的护理

Nursing for patients with refractory idiopathic thrombocytopenic purpura by combination treatment of small dose of rituximab and recombinant human thrombopoietin

目的探讨小剂量美罗华联合重组人血小板生成素(rh TPO)治疗难治性特发性血小板减少性紫癜(ITP)的疗效及其护理。方法对诊断为难治性ITP的4例患者采用小剂量美罗华联合rh TPO治疗,治疗过程中实施有效的心理护理,严格规范药液的保管、配置及输注,积极预防和处理药物不良反应,并对副作用进行严密观察和护理。结果 4例患者中,1例获完全反应(CR),3例获部分反应(PR),发热1例、肝功能异常1例,所有患者均顺利完成治疗。结论小剂量美罗华联合rh TPO为难治性ITP的治疗提供了新途径,是一种安全有效的治疗方法,精心的护理能有效预防药物的毒副作用,保证治疗效果。

Objective To explore the efficacy and nursing for patients with refractory idiopathic thrombocytopenic purpura（ ITP） by combination treatment of small dose of rituximab and recombinant human thrombopoietin（ rh TPO）. Methods Four patients diagnosed as refractory ITP were treated with small dose of rituximab and rh TPO,and meanwhile they were conducted with effective psychological nursing,strict regulation of liquid storage,configuration and infusion,positive prevention and management of adverse drug reactions. Side effects were observed strictly. Results Four patients completed treatment successfully,and there were one case of CR,3 cases of PR,one case of fever and one case of abnormal liver function. Conclusion Small dose of rituximab combined with rh TPO is a new way for treatment of refractory ITP. Careful nursing care can effectively prevent the side effects of drug and ensure the therapeutic effect. P.