乌鲁木齐市社区居民非酒精性脂肪肝流行现状调查

Prevalence of and risk factors for nonalcoholic fatty liver disease in community residents in Urumqi city

目的:本调查旨在了解乌鲁木齐市社区居民非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)患病情况及其主要相关危险因素,从而为今后开展该病的防治提供依据.方法:以街道社区为单位,采取整群抽样的方法,通过问卷调查、体格测量、血液生化(包括肝功能、空腹血糖)检查以及肝脏B超检查,调查NAFLD患病情况.结果:对乌鲁木齐市2个社区调查1000例,最终符合纳入标准的社区居民共有844例,其中男性291例,女性553例,平均年龄51.66岁±7.10岁,汉族558例,维吾尔族272例,回族13例.检出NAFLD患者456例,患病率为54.0%.对各项临床指标分析显示少数民族居民NAFLD患病率高于汉族居民.NAFLD组人群的体质量指数、收缩压、舒张压、腰围、臀围、颈围、皮下脂肪厚度、空腹血糖、尿酸、谷丙转氨酶、谷草转氨酶水平均高于正常人群组.结论:乌鲁木齐市区40-65岁社区居民NAFLD患病率较高,少数民族人群NAFLD高于汉族人群,其中体质量指数、收缩压、腰围、皮下脂肪、空腹血糖、尿酸、丙氨酸氨基转移酶均是NAFLD的危险因素.

AIM：To investigate the prevalence of and risk factors for nonalcoholic fatty liver disease（NAFLD） among community residents in Urumqi in order to provide evidence for the prevention and treatment of this disease in the future.METHODS：Cluster sampling method was adopted in this study.Questionnaire survey,physical measurement,blood biochemistry（including liver function,fasting blood sugar）examination as well as liver B ultrasound were used to investigate the situation of NAFLD.RESULTS：A total of 844 people met the inclusion criteria for community residents,including 291 men and 553 women,with an average age of 51.66 years ± 7.10 years,of whom 558 were Han Chinese,272 were Uygur,and 13 were Hui.The overall prevalence rate of NAFLD was 54%.The prevalence rate of NAFLD among ethnic minority residents was higher than that of Han nationality.Body mass index,systolic blood pressure,diastolic blood pressure,waist circumference,hip circumference,neck circumference,subcutaneous fat thickness,fasting blood glucose,uric acid,alanine aminotransferase,and aspartate aminotransferase levels were significantly higher in NAFLD than in the normal group.CONCLUSION：The prevalence rate of NAFLD in community residents aged 40-65 years is higher in Urumqi.BMI,waist circumference,subcutaneous fat,fasting blood glucose,and alanine aminotransferase are risk factors for NAFLD.