清肝化纤汤联合阿德福韦酯治疗慢性乙型肝炎随机平行对照研究

Qinggan Huaxian(清肝化纤汤) and Adefovir Treating for Chronichepatitis B Randomized ParallelControlled Study

[目的]观察清肝化纤汤联合阿德福韦酯治疗慢性乙型肝炎疗效。[方法]使用随机平行对照方法,将80例住院及门诊患者按就诊顺序号方法简单随机分两组。对照组40例阿德福韦酯,10m∥次,1次/d。治疗组40例清肝化纤汤(茵陈30g,山栀子10g,板蓝根30g,虎杖、人字草、叶下珠各15g,丹参20g,白术、茯苓、猪苓、郁金、枳壳各15g,五味子10g),1剂/d,水煎200mL,早晚口服;阿德福韦酯治疗同对照组。连续治疗48周为1疗程。观测临床症状、症状积分、ALT、AST、抗病毒治疗应答、不良反应。治疗1疗程(48周),随访3个月,判定疗效。[绪果]临床疗效治疗组优于对照组(P<0.05)。肝功能指标两组均有改善(P<0.05),治疗组改善优于对照组(P<0.05)。完全应答率、部分应答率、ALT复常率、HBV-DNA阴转率治疗组均优于对照组(P<0.05)。[结论]清肝化纤汤联合阿德福韦酯治疗慢性乙型肝炎,疗效满意,无严重不良反应,值得推广。

[Objective] To observe Qinggan Huaxian and Adefovir treating for chronichepatitis B patients. [Method] Random parallel control method, 80 patients hospitalized and outpatient treatment order randomly divided into two simple numbers. The control group of 40 patients adefovir dipivoxil,10mg/times, 1 times/d. Treatment group, 40 patients Liver fiber soup （capillaris 30g,mountain gardenia 10g, Radix 30g, Polygonum cuspidatum, KSC, Phyllanthus each 15g, Salvia 20g, Poria, Polyporus, turmeric, Citrus aurantium each 15g Schisandra 10g）, l/d, decoction 200mL, sooner or later oral; western medicine with the control group. For 48 consecutive weeks as a course of treatment. Observation of clinical symptoms,symptom score, ALT, AST, antivira] treatment response, side effects. One course of treatment （48 weeks）,followed up for 3 months to determine efficacy. [Results] The clinical efficacy of the treatment group than the control group （P〈0.05）. Liver function improved in both groups （P〈0.05）,treatment group was better than that in the control group （P〈0.05）. Complete response rate, partial response rate, ALT normalization rate, HBV-DNA negative rate of the treatment group than the control group （P〈0.05）.[Conclusion] Liver fiber soup combined with adefovir dipivoxil treatment of chronic hepatitis B, results were satisfactory, no serious adverse reactions,should be promoted.