军队腺病毒感染217例临床分析

Clinical Analysis of 217 Cases of Military Adenovirus Infection

目的分析军队腺病毒疫情的临床特点,为临床诊断及治疗提供参考。方法收集一起军队腺病毒感染住院病人217例的临床表现、影像学检查、实验室检查等相关临床资料行回顾性统计分析。结果从三大常规及生化分析看,肺炎患者与上呼吸道感染患者比较,血红蛋白、心肌酶谱、尿液分析的变化有统计学差异(P<0.05)。从炎性指标看,大面积肺炎组(累及肺叶大于2个)与上呼吸道感染组进行比较:血沉(erythrocyte sedimentation rate,ESR)、C反应蛋白(C-reaction protein,CRP)、降钙素原(procalcitonin,PCT)差异有统计学意义(P<0.05),白细胞介素6(interleukin6,IL-6)无统计学差异。结论腺病毒感染发病急,可短期导致军内呼吸道疾病流行,多数伴有呼吸道症状,其他系统症状轻微。炎性指标明显升高、心肌酶异常、贫血、尿液分析异常为重症的临床特征,需重视。

Objective To analyze the clinical characteristics of military adenovirus infection and provide references for clinical diagnosis and treatment in the future.Methods The clinical manifestations,imaging examination,laboratory examination and other related clinical data of 217 military patients with adenovirus infection were collected and retrospectively analyzed.Results The changes of hemoglobin,myocardial enzyme spectrum and urine analysis were statistically different between patients with pneumonia and upper respiratory tract infection（P〈0.05）.From the perspective of inflammatory markers,the massive pneumonia group（number involved lobes 〉2）and upper respiratory tract infection group were compared and their erythrocyte sedimentation rate（ESR）,and C-reactive protein（CRP）,calcitonin gene-related peptide（PCT）were significantly different（P〈0.05）,while interleukin 6（IL-6）was not significantly different.Conclusion The incidence of adenovirus infection is acute.It can cause military respiratory diseases in the short term with mostly respiratory symptoms and mild symptoms in other systems.Inflammatory indexes（including ESR,CRP,PCT）are significantly elevated.Myocardial enzyme abnormalities,anemia,and abnormal urine analysis may be the clinical features of severe adenovirus infection,which should be focused.