脑血康口服液联合尼莫地平对高血压性脑出血疗效及患者血清Tau蛋白、IGF-1及hs-CRP的影响

Effect of Naoxuekang Oral Liquid Combined with Nimodipine on Hypertensive Cerebral Hemorrhage and the Influence on Serum Tau Protein,IGF-1 and Hs-CRP in Patients

目的:观察脑血康口服液联合尼莫地平治疗高血压性脑出血的疗效及其对患者血清Tau蛋白、胰岛素样生长因子-1(IGF-1)及超敏C反应蛋白(hs-CRP)的影响。方法:98例高血压性脑出血患者随机分为观察组(49例)和对照组(49例)。两组均给予常规治疗同时,对照组予尼莫地平注射液治疗,观察组在对照组基础上加用脑血康口服液。两组均治疗4周。比较两组患者治疗前后血清Tau蛋白、IGF-1及hs-CRP水平,以及美国国立卫生研究院卒中量表评分(NIHSS)、血肿体积变化;评价两组临床疗效和药品不良反应。结果:治疗后,两组血清Tau蛋白、hs-CRP水平、NIHSS评分及血肿体积均较治疗前显著降低(P<0.05),且观察组治疗2周后和4周后水平均低于对照组(P<0.05);两组血清IGF-1水平较治疗前升高(P<0.05),且观察组治疗2周后和4周后水平高于对照组(P<0.05)。观察组治疗有效率显著高于对照组(89.8%vs.73.5%,P<0.05);两组的不良反应发生率差异无统计学意义(P>0.05)。结论:脑血康口服液联合尼莫地平能够显著降低高血压性脑出血患者的血清Tau蛋白与hs-CRP水平,提高IGF-1水平,改善患者神经缺损症状,有利于患者的康复。

Objective：To observe the effects of Naoxuekang oral liquid combined with nimodipine on hypertensive cerebral hemorrhage and the influence on serum Tau protein,IGF-1 and hs-CRP in the patients.Methods：Totally 98 patients with hypertensive cerebral hemorrhage were randomly divided into two groups（n = 49）.The patients in the control group were given nimodipine,while those in the observation group were given nimodipine and Naoxuekang oral liquid at the same time,and all the patients received 4-week treatment.The serum levels of Tau protein,IGF-1 and hs-CRP before and after the treatment were detected,and the national institutes of health stroke scale（NIHSS） score,hematoma volume and curative effect and adverse drug reaction were recorded as well.Results：Before the treatment,there was no significant differences in Tau protein,hs-CRP,IGF-1,NIHSS score and hematoma volume between the two groups（P〉0.05）.After the treatment,the levels of Tau protein and hs-CRP,NIHSS score and hematoma volume in both groups were decreased,and those in the observation group were lower than those in the control group;the IGF-1 level in both groups was increased,and that in the observation group was higher than that in the control group;and all the differences had statistical significance（P〈0.05）.There was no significant difference in the complication rate between the groups（P〈0.05）,while the effective rate of the observation group was significantly higher than that of the control group（89.8% vs 73.5%,P〈0.05）.Conclusion：Naoxuekang oral liquid combined with nimodipine can significantly reduce the serum levels of Tau protein and hs-CRP,and increase the serum level of IGF-1,and improve the symptoms of patients with hypertensive cerebral hemorrhage,which is beneficial to the rehabilitation of patients.