长春西汀注射液临床使用调查

Research on Clinical Application of Vinpocetine Injection

目的:调查长春西汀注射液临床使用及不良反应发生情况。方法:统计分析某院神经内科2013年12月~2014年12月住院患者中长春西汀注射液的使用情况。检索关于长春西汀注射液不良反应的相关文献并做统计分析。结果:363例患者使用长春西汀注射液输注浓度均大于0.06 mg·ml^(-1),发生不良反应3例,主要表现为皮疹及药物热。检索获得28篇文献中使用长春西汀注射液浓度高于0.06 mg·ml^(-1)的有19篇,8篇文献出现了不同程度的不良反应。结论:临床医生在临床用药过程中应重视说明书的应用,提高药物的安全合理应用。

Objective：To investigate the clinical application and adverse events of vinpocetine injection.Methods：The application of vinpocetine injection in the patients in neurology department during December 2013 and December 2014 in a hospital was statistically analyzed.The adverse reactions of the injection reported in the professional literatures and relevant documents were also retrieved and statistically analyzed.Results：The infusion concentration of vinpocetine injection for 363 patients was more than 0.06 mg·ml^-1,and 3 cases of adverse reactions appeared with the main symptoms of rash and drug fever.Among 28 published literatures,19 articles were with the infusion concentration of vinpocetine injection above 0.06 mg·ml^-1 and 8 articles reported adverse reactions in varying degrees.Conclusion：Clinicians should pay attention to the instructions in the clinical course of medication in order to improve the safe and rational use of drugs.