摘要
目的通过对预先埋植有DSI遥测植入子的清醒Beagle犬皮下注射给予牛蒡子苷元注射液（NBZGY）,评价对Beagle犬心血管系统和呼吸系统产生的潜在影响。方法采用8只已经成功埋植DSI遥测植入子（TL11M2-D70-PCTR）的Beagle犬,皮下注射给予NBZGY（0.05~5 mg·kg-1）,每只清醒Beagle犬将在4个独立的给药日分别给予溶媒及3个剂量的NBZGY,每次给药间隔（含给药日）为2天。通过生理信号遥测系统连续测量和记录给药前、给药后1、1.5、2、3、4、5、6、12、24 h的心电（RR间期、心率、T波振幅、ST段、QRS间期、PR间期、QT间期）、体温、血压（收缩压、舒张压、平均压）、呼吸（潮气量、呼吸频率）等指标。结果给药后1、2、24 h,部分指标与同期溶媒对照组相比具有统计学意义（P〈0.05）,但因差异无剂量依赖性,故无生物学意义。结论本实验条件下,Beagle犬皮下注射给予NBZGY,心血管系统和呼吸系统均未见与供试品相关的明显改变。
Objective To evaluate the effects of arctigenin injection（NBZGY）on the cardiovascular system and the respiratory system by subcutaneous administration in conscious Beagle dogs that implanted with telemetry transmitters. Methods Eight Beagle dogs with telemetry transmitters（TL11M2-D70-PCTR）were subcutaneously administrated with NBZGY injection（0.05~5 mg·kg-1） and 30% PEG（normal control）. All dogs received normal control and NBZGY injection in sequence every other day. The ECG（RR interval, heart rate, T wave, ST segment, QRS interval, PR interval, QT interval）, body temperature, blood pressure（systolic blood pressure, diastolic blood pressure, mean blood pressure） and respiratory（tidal volume, respiratory rate） data were continuously monitored for at least 2 h before dosing and 1, 1.5, 2, 3, 4, 5, 6, 12 and 24 h after dosing. Results Compared with the vehicle control group at 1, 2, 24 h after dosing, tidal volume, respiratory rate increased signifi cantly（P 0.05）, RR interval,diastolic blood pressure, mean blood pressure reduced signifi cantly（P 0.05）. Conclusion Under these study condictions,no obvious change in the cardiovascular system and the respiratory system of Beagle dogs was found after subcutaneous administration with NBZGY.
出处
《中国药物警戒》
2016年第4期197-200,共4页
Chinese Journal of Pharmacovigilance
基金
山东省自主创新及成果转化专项(创新型产业集群):2015ZDJQ05004
