应用超选择动脉灌注化疗治疗残胃复发癌

Superselective intra-arterial infusion chemotherapy for recurrent cancer in the remnant stomach after partial gastrectomy

目的评价超选择靶区动脉置泵灌注化疗治疗晚期残胃复发癌的疗效。方法对我院经术中证实不能手术切除的18例残胃复发癌,术中超选择靶区动脉置泵,术后灌注化疗的疗效进行分析。结果化疗后,临床症状均有不同程度的改善。肿瘤病灶完全缓解1例,部分缓解13例,稳定2例,恶化2例,有效率为77.8%。肿瘤细胞病理学改变有效率为83.3%。0.5、1.0、1.5、2.0年生存率分别为94.4%、66.7%、50.0%和27.8%。结论超选择动脉灌注化疗是治疗晚期残胃复发癌的有效方法,可以明显延长患者的带癌生存期。

Objective To investigate the effect of superselective intra-arterial infusion chemotherapy in the treatment of advanced recurrent cancer in the remnant stomach after previous partial gastrectomy. Methods Eighteen patients with advanced recurrent cancer in the remnant stomach that were non-resectable as confirmed in the operations were included in this study, who subsequently received superselective intra-arterial infusion chemotherapy. Results Improvement of the symptoms to various degrees were achieved in all patients after the therapy, with the total rate of tumor reduction of 77.8% and pathologically confirmed improvement rate of 83.3%. The 0.5-, 1.0-, 1.5- and 2.0-year survival rates were 94.4%, 66.7%, 50.0% and 27.8% respectively. Conclusion Superselective catheterization is effective in treatment of advanced recurrent cancer in the remnant stomach, which can significantly prolong the tumor-bearing survival period of the patients.