每日疗法与间歇疗法在糖尿病并初治涂阳肺结核患者中的应用

Application and comparison of everyday therapy and intermittent treatment in the patients with diabetes and smear positive pulmonary tuberculosis

目的比较每日疗法与间歇疗法在糖尿病并初治涂阳肺结核患者中的疗效。方法选择本院2013年5月至2014年10月收治的糖尿病并初治涂阳肺结核患者共82例作为研究对象,均采用糖尿病饮食、运动疗法及药物治疗,同时采用每日疗法进行结核化疗的42例作为观察组,采用间歇疗法进行结核化疗的40例作为对照组,比较两组患者的血糖控制、痰菌转阴以及结核病灶吸收情况。结果治疗后3个月比较两组患者的空腹血糖以及餐后2 h血糖,差异均无统计学意义（t=1.00、0.41,P均〉0.05）;治疗后6个月比较两组患者的空腹血糖以及餐后2 h血糖,差异均无统计学意义（t=0.79、0.53,P均〉0.05）;治疗后2、3和6个月观察组患者痰菌转阴率分别为73.8%、90.5%和97.6%,对照组分别为65.0%、72.5%和80.0%,治疗后3、6个月观察组患者痰菌转阴率显著高于对照组,组间差异具有统计学意义（χ^2=4.43、4.83,P均〈0.05）;治疗后6个月观察组的结核病灶吸收显效率为88.1%,显著高于对照组（70.0%）,组间差异具有统计学意义（χ^2=4.08、P〈0.05）。结论每日疗法在糖尿病并初治涂阳肺结核患者中的应用疗效更佳,能够更好地促进痰菌转阴率以及结核病灶吸收,可作为高效的治疗方案。

Objective To compare the application effect of orthopedic and rehabilitation of anterior fixation and posterior fixation in the treatment of diabetic patients complicated with spinal tuberculosis. Methods From May 2013 to October 2014, a total of 82 cases of diabetes and smear positive tuberculosis in our hospital were selected, who were administered diet control, exercise therapy and medication, and 42 cases were treated with everyday therapy as the observation group, 40 cases were treated with intermittent treatment as the control group, the glycemic control, negative sputum bacillus and tuberculosis absorption data of two groups were compared, respectively. Results Three months after treatment, the fasting plasma glucose and 2 h postprandial glucose of two groups were compared, with no significant differences（t = 1.00, 0.41; P all〉 0.05）; 6 months after treatment, the fasting plasma glucose and 2h postprandial glucose of two groups were compared, with no significant differences（t = 0.79, 0.53; P all 〉0.05）; 2, 3 and 6 months after treatment, the negative sputum bacillus rates of observation group were 73.8%, 90.5% and 97.6%, while the control group were 65.0%, 72.5% and 80.0%, respetively. The negative sputum bacillus rates of observation group after 3 and 6 months of treatment were significantly higher than those of the control group, with significant differences（χ~2 = 4.43, 4.83; P all 〈0.05）; the tuberculosis markedly absorption of observation group after 6 months of treatment was 88.1%, significantly higher than that of the control group（70.0%）, with significant difference（χ~2 = 4.08, P〈 0.05）. Conclusions Everyday therapy in the patients with diabetes and smear positive pulmonary tuberculosis has better effect, which would be able to promote sputum negative absorption rate and tuberculosis, and could be taken as highly effective drug treatment programs.