度洛西汀治疗女性盆底网片重建术后慢性盆腔疼痛的疗效

Duloxitine for treatment of chronic postoperative pelvic pain in women after reconstructive pelvic surgery

目的观察度洛西汀对女性盆底网片重建术后慢性盆腔疼痛的疗效。方法选取女性盆底网片重建手术后的慢性盆腔疼痛患者40例,并用随机数字表法将其随机分为治疗组和对照组,每组20例。所有入组患者数字化疼痛评分(NRS)≥4分,汉密尔顿抑郁量表-17(HAMD-17)评分≥17分,汉密尔顿焦虑量表(HAMA)评分≥14分。治疗组、对照组均给予布洛芬缓释胶囊作为基础治疗;另外治疗组再给予度洛西汀胶囊60 mg,每日1次口服,疗程8周。治疗前后两组患者分别进行NRS、HAMA和HAMD-17评分。结果与治疗前相比,治疗组NRS、HAMA、HAMD-17的分值明显下降(P<0.05)。结论度洛西汀对女性盆底网片重建术后慢性盆腔疼痛具有较好的辅助治疗作用。

Objective To evaluate the efficacy of duloxitine for treatment of chronic postoperative pelvic pain in women following reconstructive pelvic surgery. Methods Forty patients with chronic postoperative pelvic pain following reconstructive pelvic surgery with mesh were randomly assigned in treatment group and control group with 20 cases in each. All subjects had numeric rating scale（NRS） ≥ 4, Hamilton Depression Scale （ HAMD-17 ） ≥ 17 and Hamilton Anxiety Scale （HAMA） ≥ 14. Patients in both groups were given buprofen sustained release capsules as the basic remedy; and additional antidepressant agent duloxitine was given to patients in treatment group （60 mg once a day, orally for 8 weeks）. The scores of NRS, HAMD-17 and HAMA were compared between two groups.Results The decrease of NRS, HAMD-17 and HAMA scores in treatment group was significant greater than that in control group. Conclusion Duloxitine is effective for postoperative chronic pelvic pain in patients after reconstructive pelvic surgery with mesh.