重组人干扰素α-1b治疗婴幼儿急性毛细支气管炎疗效及成本评价

Evaluation of therapeutic effect and cost of recombinant human interferon α-1b in treatment of acute bronchiolitis in infants

目的评价重组人干扰素α-1b治疗婴幼儿急性毛细支气管炎的临床疗效及治疗成本。方法采用随机、对照临床研究,将70例急性毛细支气管炎患儿分为实验组及对照组,每组35例,实验组在常规治疗基础上加用注射用重组人干扰素α-1b,1μg/(kg·d),1次/d,肌内注射;对照组在常规治疗基础上加用0.9%氯化钠注射液50 ml和利巴韦林注射液15mg/(kg·d),分2次,静脉滴注。比较两组患儿治疗总有效率;观察两组患儿咳嗽、喘憋、肺部哮鸣音、湿啰音消失时间和住院天数,并统计其治疗成本。结果实验组及对照组总有效率分别为97.2%和82.8%,两组比较差异有统计学意义(χ2=19.78,P<0.05)。两组患儿均治愈出院,实验组住院天数(4.09±1.21)d,明显短于对照组(7.54±1.59)d,两组比较差异有统计学意义(t=6.79,P<0.01);实验组临床症状、体征消失时间和治疗成本明显优于对照组(P<0.01)。结论重组人干扰素α-1b治疗急性毛细支气管炎疗效显著并可降低治疗成本。

Objective To evaluate the therapeutic effect and treatment cost of recombinant human interferon α-1b on acute bronchiolitis in infants. Methods In this randomized and controlled clinical study,70 children with acute bronchiolitis were divided into the study group and the control group with 35 cases each. The study group received recombinant human interferon α-1b [1 μg /（ kg·d）,1 time/d,intramuscular injection]in addition to the conventional treatment. The control group received 50 ml saline and ribavirin [15 mg /（ kg·d）,twice,intravenous infusion] in addition to the conventional treatment. The total efficacy of the treatment on the two groups was compared. Coughing,wheezing,lung wheezes,crackles and days of hospitalization of the two groups were observed,and their treatment costs were statistically analyzed. Results The treatment efficacy in the study group was significantly higher than in the control group,with 97. 2% and 82. 8% respectively（ χ2= 19. 78,P 〈0. 05）. All patients were cured. Hospitalization days were4. 09 ± 1. 21 and 7. 54 ± 1. 59 in the study group and the controll group,respectively,with statistical significant difference. The disappearance time of symptoms and signs was significantly shorter and the treatment cost was significantly lower in the study group than in the control group（ t = 6. 79,P 〈0. 01）. Conclusions Using recombinant human interferon α-1b as treatment of acute bronchiolitis can significantly improve the therapeutic effect and reduce the treatment cost.