2型糖尿病白蛋白尿相关因素分析

Risk Factors of Albuminuria in Type 2 Diabetes Mellitus

目的:探索2型糖尿病患者白蛋白尿的患病相关危险因素。方法:311例2型糖尿病患者按尿白蛋白/尿肌酐(ACR)比值分为三组:正常蛋白尿组(NDN)、微量白蛋白尿组(MAU)、大量蛋白尿组(CAU),比较三组间各项指标等差别,并对白蛋白尿组(包括微量蛋白尿与大量蛋白尿)采用多元logistic回归分析与蛋白尿相关的因素。结果:与正常组相比,微量白蛋白尿组的年龄,FPG,TG升高,C肽下降,(P<0.05);大量蛋白尿组的病程、DBP、FPG、HBA1C、TG、LDL-C、Cr、SUA也升高(P<0.05);大量蛋白尿组与微量白蛋白尿组相比,年龄、HBA1C、LDL-C、SUA也较高(P<0.05)。SBP、HBA1C、TG、病程在多元logistic回归分析具有统计意义(P<0.05)。结论:2型糖尿病患者白蛋白尿与以下因素有关:血压、血脂和血糖控制不良、病程等,针对相关的因素进行分析,对于糖尿病肾病早诊断、早治疗有积极的意义,另外对于延缓糖尿病肾病的发生也有非常重要的作用。

Objective:To investigate the risk factors of albuminuria in type 2 diabetes mellitus.Methods:The 311 cases of type2 DM Were divided into three group by the ratio of albuminuria and creatinine(ACR),The difference between normal albuminuria group(NDN),microalbuminuria group(MAU),macroalbuminuria group(CAU),compare the three groups of indicators,and albuminuria group(including microalbuminuria and proteinuria) multivariate logistic regression analysis of factors associated with albuminuria.Results:Compared with normal group,age microalbuminuria group,FPG,TG increased,C peptide decreased,(P<0.05);duration macroalbuminuria group,DBP,FPG,HBAlC,TG,LDL-C,Cr,SUA also increased(P<0.05);macroalbuminuria compared with microalbuminuria group,age,HBA1 C,LDL-C,SUA also higher(P<0.05).SBP,HBA1 C,TG,course in multivariate logistic regression analysis of statistical significance(P<0.05).Conclusion:Albuminuria in patients with type 2 diabetes,the following factors:blood pressure,blood lipids and poor glycemic control,duration,etc.,are analyzed for factors associated,for diabetic nephropathy early diagnosis,early treatment has a positive meaning,in addition to delaying the occurrence of diabetic nephropathyalso it has a very important role.