68例危急重症有机磷中毒患者的临床急救措施及救治成功的预后分析

Analysis of Clinical Emergency Measures and Prognosis in Patients with Successful Treatment of 68 Cases of Severe Organophosphorus Poisoning

目的:探讨危急重症有机磷中毒患者的临床急救措施及救治成功的预后情况。方法:对我院收治的68例危重症有机磷中毒患者一般资料进行回顾性分析,并随机分成观察组和对照组,对照组采取常规急救处理,观察组在对照组的急救治疗基础上加用血液灌流、血液透析治疗,对比两组治治疗效果以及救治成功后的预后情况。结果:观察组阿托品化时间、胆碱酯酶活性恢复时间、意识恢复时间、呼吸机治疗脱机时间、住院时间均短于对照组(P<0.05),阿托品使用总量显著低于对照组(P<0.05),GCS评分显著高于对照组(P<0.05),APACHEⅡ评分显著低于对照组(P<0.05),观察组患者死亡率、中毒反跳发生率均显著低于对照组(P<0.05)。结论:对危重症有机磷中毒患者的常规急救基础上联合使用血液灌流、血液透析治疗,可提高救治效果,改善患者预后。

Objective:To investigate the clinical emergency treatment and the prognosis of patients with severe organic phosphorus poisoning.Methods:Selected 68 critically ill organophosphate poisoning patients and conducted retrospective analysis,randomly divided them into observation group and control group.The control group was given general first aid,the observation group was treated with perfusion and hemodialysis on the basis of control group.Compared these two groups' treatment effects and prognosis.Results:The observation group's atropine time,cholinesterase activity recovery time,consciousness recovery time,ventilator therapy offline time and hospital-stay time were all obviously shorter than the control group(P<0.05);its total amount of atropine using was significantly lower than the control group(P<0.05);its GCS score was obviously higher than the control group(P<0.05);its APACHE II score was significantly lower than the control group(P<0.05);ant its mortality rate,the incidence of poisoning rebound were both obviously lower than the control group(P<0.05).Conclusion:Using perfusion and hemodialysis on the basis of general first aid can improve treatment effects and prognosis when treating patients with critically ill organophosphate poisoning.