甲状旁腺激素影响老年骨质疏松性骨折愈合的临床观察与安全性分析

Clinical Observation and Security Analysis of Parathyroid Hormone on the Healing of Elderly Osteoporotic Fracture

目的通过临床观察探讨甲状旁腺激素（PTH）对老年骨质疏松性骨折愈合的影响作用.方法：选择我院30例老年骨质疏松性骨折患者,随机分为对照组和治疗组,每组各15例,所有病例均采用卧硬板床保守治疗,对照组患者口服碳酸钙D3片600mg/天,治疗组在对照组治疗基础上每天皮下注射20ug PTH,连续治疗12周.并分别对第3周、6周、9周和12周所有患者治疗效果、腰椎L2～L4骨密度（BMD）及骨折端骨痂生长情况进行统计学分析.结果：治疗组与对照组的总有效率分别为93.3%和53.3%,两组比较差异具有统计学意义（P〈0.05）.PTH治疗期间未见明显不良反应.结论：PTH对于治疗老年骨质疏松性骨折愈合效果明显,并无明显不良反应.

Objective:To investigate the clinical efficacy and the influence of parathyroid hormone in the treatment of osteoporotic compression fracture in the elderly.Methods:30 patients admitted by our hospital with osteoporosis fracture were randomly divided into two groups,control group and treatment group,control group including 6 cases of men,9 cases of women;treatment group including 8 cases of men,7 cases of women.All cases were treated with conservative treatment,guided with proper motion,and changed bad living habits.Patients in control group were treated with calcium D3 tablets 600 mg/day alone;the treatment group were treated with 20 ug PTH per day subcutaneous injection in the foundation of the control group.The fracture healing in the two groups after medication for 12 consecutive weeks were evaluated.The treatment effect,bone mineral density(BMD)(lumbar L2-L4) and fracture callus growth for all patients were in statistical analysis after 3 weeks,6 weeks,9 weeks and 12 weeks respectively.Results:The total effective rate in treatment group and control group were 93.3%and 53.3%respectively,comparing the two groups statistically significant difference(P<0.05);No adverse reactions during the PTH treatment.Conclusion:The effect of PTH for patients with osteoporosis fracture is insignificant,and there is no adverse reaction in the whole treatment.