雾化吸入伊洛前列素对新生儿持续性肺动脉高压的临床疗效

Efficacy of iloprost inhalation of persistent pulmonary hypertension of the newborn

目的观察雾化吸入伊洛前列素对新生儿持续性肺动脉高压的临床疗效。方法 40例新生儿持续性肺动脉高压患儿随机分为试验组和对照组,每组20例。对照组雾化吸入0.9%NaCl;试验组雾化吸入伊洛前列素1~2μg·kg^(-1),吸入时间为5~10 min,连续治疗3 d。观察2组的临床疗效及治疗前后的平均肺动脉压、动脉血氧分压(PaO_2)指标变化。结果试验组治疗有效率为75%,显著高于对照组的5%(P<0.05)。试验组治疗前后平均肺动脉压分别为(25.95±3.35),(18.55±2.45)mmHg;对照组分别为(24.45±3.65),(24.55±3.75)mmHg;治疗后,试验组平均肺动脉压显著低于治疗前和对照组(P<0.05)。试验组治疗前后动脉血氧分压分别为(45.66±4.73),(63.13±5.55)mmHg;对照组分别为(43.25±4.33),(43.13±4.55)mmHg,治疗后,试验组动脉血氧分压显著高于治疗前和对照组(P<0.05)。结论雾化吸入伊洛前列素治疗新生儿持续肺动脉高压有一定的临床疗效。

Objective To explore the clinical effect of iloprost atomizating inhalation on persistent pulmonary hypertension newborns（ PPHN）.Methods Forty newborns with persistent pulmonary hypertension were randomly divided into treatment group and control group,20 cases in each group. Newborns in control group were treated with 0. 9% Na Cl,atomizating inhalation. Newborns in treatment group were treated with iloprost inhalation 1- 2 μg ·kg^-1,inspiratory time 5-10 minutes per day for 3 d. Mean pulmonary artery pressure（ PAMP）,arterial partial pressure of oxygen（PaO2） were observed of the two groups before and after treatment. The clinical effects were compared between the two groups. Results Total effective rate of treatment group was 75%,significantly higher than 5% in control group（ P〈0. 05）. The PAMP were（ 25. 95 ± 3. 35）,（ 18. 55 ± 2. 45） mmHg in treatment group; and（ 24. 45 ± 3. 65）,（ 24. 55 ± 3. 75） mmHg in control group before and after treatment. The PAMP in treatment group after treatment was significantly lower than that in control group and before treatment（ P〈0. 05）. The PaO2 were（ 45. 66 ± 4. 73）,（ 63. 13 ± 5. 55） mmHg in treatment group,and（ 43. 25 ± 4. 33）,（ 43. 13 ± 4. 55） mmHg in control group before and after treatment. The PaO2 in treatment group after treatment was significantly lower than that in control group and before treatment（ P〈0. 05）. Conclusion Inhalating iloprost had clinical effect in newborns of persistent pulmonary hypertension.